Potassium cyanate → N-[4-[2-(1H-Imidazol-1-yl)ethoxy]phenyl]urea

HRID 980148Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 980148
[NH2:1][C:2]1[CH:15]=[CH:14][C:5]([O:6][CH2:7][CH2:8][N:9]2[CH:13]=[CH:12][N:11]=[CH:10]2)=[CH:4][CH:3]=1.[O-:16][C:17]#[N:18].[K+]>Cl.O>[NH:1]([C:2]1[CH:3]=[CH:4][C:5]([O:6][CH2:7][CH2:8][N:9]2[CH:13]=[CH:12][N:11]=[CH:10]2)=[CH:14][CH:15]=1)[C:17]([NH2:18])=[O:16]

Komponenten

5

Edukt 2

HCID 11378442Potassium cyanateHCID 135692034-[2-(1H-Imidazol-1-yl)ethoxy]aniline

Produkt 1

HCID 13569204N-[4-[2-(1H-Imidazol-1-yl)ethoxy]phenyl]ureaAusbeute 82,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

1-[2-(4-Aminophenoxy)ethyl]imidazole (0.6 g) was dissolved in 1N hydrochloric acid (3.0 ml) and a solution of potassium cyanate (0.3 g) in 1 ml of water was added. The mixture was allowed to stand at room temperature for 15 minutes and the resulting solid was filtered off, washed with water and crystallised from water to give 1-[2-(4-ureidophenoxy)ethyl]imidazole (0.6 g), m.p. 199°-201° C. Found: C, 58.20; H, 5.70; N, 23.06. C12H14N4O2 requires: C, 58.52; H, 5.73; N, 22.75%.

Aufarbeitung

  1. filtrationthe resulting solid was filtered off
  2. washwashed with water
  3. customcrystallised from water

Quellen und Nachweise

ORD-Eintrag
ord-bb0891538fbb440d862e6ab28e6776b4
Quelldatensatz
uspto-grants-1987_01
Patentnummer
US04636500

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