4-(Chloromethyl)-6-methoxypyrimidin-2-amine → 2-Amino-4-methoxy-6-dimethylthiocarbamoylthiomethyl-pyrimidine

HRID 980766

Reaktionsgleichung

Reaktionsgleichung von HRID 980766
O.O.[Na+].[CH3:4][N:5]([CH3:9])[C:6](=[S:8])[S-:7].[NH2:10][C:11]1[N:16]=[C:15]([CH2:17]Cl)[CH:14]=[C:13]([O:19][CH3:20])[N:12]=1>C(O)C.O>[NH2:10][C:11]1[N:12]=[C:13]([O:19][CH3:20])[CH:14]=[C:15]([CH2:17][S:8][C:6](=[S:7])[N:5]([CH3:9])[CH3:4])[N:16]=1

Komponenten

5

Edukt 2

HCID 138848154-(Chloromethyl)-6-methoxypyrimidin-2-amineHCID 23693613Sodium dimethyldithiocarbamate dihydrate

Produkt 1

HCID 200708292-Amino-4-methoxy-6-dimethylthiocarbamoylthiomethyl-pyrimidine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

18.5 g of dimethyldithiocarbamic acid sodium salt dihydrate and 17.4 g of 2-amino-4-chloromethyl-6-methoxypyrimidine are refluxed in 100 ml of ethanol for 30 minutes. After the mixture has been cooled, it is diluted with about 1 liter of water, and the product which has precipitated is separated and dried. The yield is 23.0 g (89% of theory) of 2-amino-4-methoxy-6-dimethylthiocarbamoylthiomethyl-pyrimidine, m.p. 118°-120° C.

Aufarbeitung

  1. temperatureAfter the mixture has been cooled
  2. customthe product which has precipitated
  3. customis separated
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-88e6e86d7b1640fd837cbbbc5b2e19d1
Quelldatensatz
uspto-grants-1987_01
Patentnummer
US04639264

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