Phenethylamine → trans-1-Benzyl-3-benzylmethylamino-4-hydroxypyrrolidine

HRID 981096Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 981096
[CH2:1]([N:8]1[CH2:13][CH:12]2[CH:10]([O:11]2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:14]([CH2:21][NH2:22])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>O1CCOCC1.O>[CH2:1]([N:8]1[CH2:9][C@@H:10]([OH:11])[C@H:12]([NH:22][CH2:21][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:13]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 2

HCID 1001PhenethylamineHCID 98153703-Benzyl-6-oxa-3-azabicyclo(3.1.0)hexane

Produkt 1

HCID 69706831trans-1-Benzyl-3-benzylmethylamino-4-hydroxypyrrolidine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

19.4 g (0.1 mol) of 90% strength 3-benzyl-6-oxa-3-azabicyclo[3.1.0]hexane are heated under reflux with 14.5 g (0.12 mol) of benzylmethylamine in 100 ml of dioxane and 200 ml of water overnight. The mixture is extracted with CHCl3, the extracts are dried with K2CO3 and concentrated and the residue is subjected to incipient distillation up to 160° C. (oil bath temperature).

Aufarbeitung

  1. extractionThe mixture is extracted with CHCl3
  2. dry with materialthe extracts are dried with K2CO3
  3. concentrationconcentrated
  4. distillationdistillation up to 160° C. (oil bath temperature)

Quellen und Nachweise

ORD-Eintrag
ord-7f933b2324e345e2805468a76c4927de
Quelldatensatz
uspto-grants-1991_02
Patentnummer
US04990517

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