Potassium Carbonate → 1,2-Dimethyl-3-oxa-2,7-diazabicyclo[3.3.0]octane

HRID 981114Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 981114
C([N:4]1[CH2:11][C:10]2([CH3:12])[CH:6]([CH2:7][O:8][N:9]2[CH3:13])[CH2:5]1)(=O)C.[OH-].[Na+].C([O-])([O-])=O.[K+].[K+]>O>[CH3:12][C:10]12[CH2:11][NH:4][CH2:5][CH:6]1[CH2:7][O:8][N:9]2[CH3:13]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 14798Sodium HydroxideHCID 150700177-Acetyl-1,2-dimethyl-3-oxa-2,7-diazabicyclo[3.3.0]octane

Produkt 1

HCID 150700181,2-Dimethyl-3-oxa-2,7-diazabicyclo[3.3.0]octane

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

11.8 g (64 mmol) of 7-acetyl-1,2-dimethyl-3-oxa-2,7-diazabicyclo[3.3.0]octane are heated under reflux with 12 g of NaOH in 36 ml of water overnight. The mixture is saturated with K2CO3 and extracted several times with CHCl3, the extract is dried over K2CO3 and concentrated and the residue is distilled.

Aufarbeitung

  1. extractionextracted several times with CHCl3
  2. dry with materialthe extract is dried over K2CO3
  3. concentrationconcentrated
  4. distillationthe residue is distilled

Quellen und Nachweise

ORD-Eintrag
ord-82984d96c2f842a6949503cd60f56b01
Quelldatensatz
uspto-grants-1991_02
Patentnummer
US04990517

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