Diketene → N-(2-morpholin-4-ylethyl)-3-oxobutanamide

HRID 981170

Reaktionsgleichung

Reaktionsgleichung von HRID 981170
[CH2:1]=[C:2]1[O:6][C:4](=[O:5])[CH2:3]1.[NH2:7][CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1>C(OCC)C>[O:13]1[CH2:14][CH2:15][N:10]([CH2:9][CH2:8][NH:7][C:4](=[O:5])[CH2:3][C:2]([CH3:1])=[O:6])[CH2:11][CH2:12]1

Komponenten

4

Edukt 2

HCID 12661DiketeneHCID 4082852-Morpholinoethylamine

Produkt 1

HCID 4076516N-(2-morpholin-4-ylethyl)-3-oxobutanamideAusbeute 72 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel2×

Versuchsvorschrift

To a solution of diketene (23.0 ml) in diethyl ether (115 ml) was added dropwise a solution of N-(2-aminoethyl)morpholine (34.7 g) in diethyl ether (300 ml) at -40° C. After stirring for 2 hours at the same condition, the resulting precipitates were collected by filtration and dried in vacuo to give N-(2-morpholinoethyl)acetoacetamide (41.1 g, yield 72.0 %).

Aufarbeitung

  1. customthe resulting precipitates
  2. filtrationwere collected by filtration
  3. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-156528d7761e40689145260e8b9a2ed2
Quelldatensatz
uspto-grants-1991_02
Patentnummer
US04990507

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