3,4-dihydro-2H-pyran → 2H-Pyran, 2-(4-chlorobutoxy)tetrahydro-

HRID 981689

Reaktionsgleichung

Reaktionsgleichung von HRID 981689
[O:1]1[CH:6]=[CH:5][CH2:4][CH2:3][CH2:2]1.[Cl:7][CH2:8][CH2:9][CH2:10][CH2:11][OH:12]>Cl>[Cl:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][CH:6]1[CH2:5][CH2:4][CH2:3][CH2:2][O:1]1

Komponenten

4

Edukt 2

HCID 80803,4-dihydro-2H-pyranHCID 135694-Chloro-1-butanol

Produkt 1

HCID 1704882H-Pyran, 2-(4-chlorobutoxy)tetrahydro-Ausbeute 89,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidKatalysator

Versuchsvorschrift

Dihydropyran (15.5 g) was added dropwise to a mixture of 4-chlorobutanol (20 g) and hydrochloric acid (18M, 1 drop) at RT. The mixture was stirred for 30 min and washed with H2O (100 ml), aqueous NaHCO3 (1M, 50 ml) and BR (50 ml). The dried liquid was heated under reduced pressure to leave the title compound as a colourless liquid (31.9 g). T.l.c. [L] Rf 0.5.

Aufarbeitung

  1. washwashed with H2O (100 ml), aqueous NaHCO3 (1M, 50 ml) and BR (50 ml)
  2. temperatureThe dried liquid was heated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-b0a14c328c734266849ffc9d04757122
Quelldatensatz
uspto-grants-1991_02
Patentnummer
US04992474

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