Sodium Methoxide → 3,3-Dimethyl-2-methoxy-2-(4-piperidinophenyl)-oxirane

HRID 981755Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 981755
Br[C:2]([CH3:18])([CH3:17])[C:3]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:7][CH:6]=1)=[O:4].[CH3:19][O-:20].[Na+]>CO>[CH3:17][C:2]1([CH3:18])[O:4][C:3]1([O:20][CH3:19])[C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:7][CH:6]=1

Komponenten

4

Edukt 2

HCID 10942334Sodium MethoxideHCID 198795192-Bromo-2-methyl-1-(4-piperidinophenyl)-propan-1-one

Produkt 1

HCID 198794483,3-Dimethyl-2-methoxy-2-(4-piperidinophenyl)-oxirane

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

12.0 g (38.7 mmol) of 2-bromo-2-methyl-1-(4-piperidinophenyl)-propan-1-one are dissolved in 20 ml of methanol, and 7.0 g (46.4 mmol) of methanolic 30% strength sodium methylate solution are then added dropwise at room temperature. The methanol is then distilled off under reduced pressure. The residue is taken up in toluene, and the precipitated salt is filtered off. The solution is concentrated in vacuo. The brown residue, which is a slowly crystallising liquid, is directly further reacted.

Aufarbeitung

  1. distillationThe methanol is then distilled off under reduced pressure
  2. filtrationthe precipitated salt is filtered off
  3. concentrationThe solution is concentrated in vacuo
  4. customa slowly crystallising liquid

Quellen und Nachweise

ORD-Eintrag
ord-90203538269948f387bb4e179d3eab97
Quelldatensatz
uspto-grants-1991_02
Patentnummer
US04992547

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