Bromobenzene → 2-bromo-5,6,8,9-tetrahydro-5,5,9,9-tetramethyl-7H-benzocyclohepten-7-one

HRID 981802

Reaktionsgleichung

Reaktionsgleichung von HRID 981802
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:8][C:9](=[CH:11][C:12](=[O:17])[CH:13]=[C:14]([CH3:16])[CH3:15])[CH3:10].[Cl-].[Cl-].[Cl-].[Al+3]>C(=S)=S>[Br:1][C:2]1[CH:7]=[CH:6][C:5]2[C:14]([CH3:16])([CH3:15])[CH2:13][C:12](=[O:17])[CH2:11][C:9]([CH3:10])([CH3:8])[C:4]=2[CH:3]=1

Komponenten

5

Edukt 3

HCID 7961BromobenzeneHCID 10438PhoroneHCID 6451240Aluminum(III) Chloride

Produkt 1

HCID 200710292-bromo-5,6,8,9-tetrahydro-5,5,9,9-tetramethyl-7H-benzocyclohepten-7-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6348Carbon DisulfideLösungsmittel

Versuchsvorschrift

47.1 g of bromobenzene and 37.8 g of phorone are stirred at room temperature for 48 hours in the presence of 40 g of aluminum trichloride in 600 ml of carbon disulfide. The reaction mixture is then poured on to ice, extracted with diethyl ether. The extract is washed with water, dried and evaporated. After chromatography on silica gel with petroleum ether (low-boiling) and ethyl acetate (9:1) and recrystallization from hexane, there is obtained 2-bromo-5,6,8,9-tetrahydro-5,5,9,9-tetramethyl-7H-benzocyclohepten-7-one of m.p. 104°-105°.

Aufarbeitung

  1. additionThe reaction mixture is then poured on to ice
  2. extractionextracted with diethyl ether
  3. washThe extract is washed with water
  4. customdried
  5. customevaporated
  6. customAfter chromatography on silica gel with petroleum ether (low-boiling) and ethyl acetate (9:1) and recrystallization from hexane

Quellen und Nachweise

ORD-Eintrag
ord-e0cd123ba4f94544bb7cbe6331cf05fa
Quelldatensatz
uspto-grants-1991_02
Patentnummer
US04992574

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