6-(2-Pyrimidinyl)-5-hexynol → 6-(Pyrimidin-2-YL)hexan-1-OL

HRID 982378Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 982378
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[C:7]#[C:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13]>C(O)C.[Pd]>[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13]

Komponenten

4

Edukt 1

HCID 198767486-(2-Pyrimidinyl)-5-hexynol

Produkt 1

HCID 198767736-(Pyrimidin-2-YL)hexan-1-OLAusbeute 29,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel2×

Versuchsvorschrift

A solution of 6-(2-pyrimidinyl)-5-hexynol (3.09 g) in ethanol (100 ml) was added to a pre-hydrogenated suspension of 10% palladium on charcoal (1.05 g) in ethanol (50 ml) and hydrogenated at room temperature and pressure, filtered and evaporated in vacuo. The residual oil was purified by FCC eluting with ether and System C (99:1-85:15) to give the title compound as a pale yellow oil (0.93 g).

Aufarbeitung

  1. filtrationpressure, filtered
  2. customevaporated in vacuo
  3. customThe residual oil was purified by FCC
  4. washeluting with ether and System C (99:1-85:15)

Quellen und Nachweise

ORD-Eintrag
ord-5fb41320c6b84a3eb9a37cbc3c192cfe
Quelldatensatz
uspto-grants-1991_02
Patentnummer
US04996218

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