6-(Pyrimidin-5-YL)hex-5-YN-1-OL → 6-(Pyrimidin-5-yl)hexan-1-ol

HRID 982379Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 982379
[N:1]1[CH:6]=[C:5]([C:7]#[C:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13])[CH:4]=[N:3][CH:2]=1>C(O)C.[Pd]>[N:1]1[CH:6]=[C:5]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13])[CH:4]=[N:3][CH:2]=1

Komponenten

4

Edukt 1

HCID 139997526-(Pyrimidin-5-YL)hex-5-YN-1-OL

Produkt 1

HCID 135575446-(Pyrimidin-5-yl)hexan-1-olAusbeute 93,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel2×

Versuchsvorschrift

A solution of 6-(5-pyrimidinyl)-5-hexynol (3.52 g) in ethanol (20 ml) was added to a pre-hydrogenated suspension of 10% palladium on carbon (1 g) in ethanol (130 ml) and hydrogenated at room temperature and pressure. The mixture was filtered through hyflo and the filtrate evaporated in vacuo to give the title compound as a pale yellow oil (3.38 g).

Aufarbeitung

  1. filtrationThe mixture was filtered through hyflo
  2. customthe filtrate evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-902d94ae0e6f475fb5fb49a5d36508f8
Quelldatensatz
uspto-grants-1991_02
Patentnummer
US04996218

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