[6-[(6-Bromohexyl)oxy]-1-hexynyl]pyrazine → [6-[(6-Bromohexyl)oxy]hexyl]pyrazine

HRID 982394Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 982394
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][O:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]#[C:14][C:15]1[CH:20]=[N:19][CH:18]=[CH:17][N:16]=1>C(O)C.[Pd]>[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]1[CH:20]=[N:19][CH:18]=[CH:17][N:16]=1

Komponenten

4

Edukt 1

HCID 19876775[6-[(6-Bromohexyl)oxy]-1-hexynyl]pyrazine

Produkt 1

HCID 19876745[6-[(6-Bromohexyl)oxy]hexyl]pyrazineAusbeute 87,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel2×

Versuchsvorschrift

A solution of [6-[(6-bromohexyl)oxy]-1-hexynyl]pyrazine (2.76 g) in ethanol (70 ml) was added to a pre-hydrogenated suspension of 10% palladium on carbon (2.00 g) in ethanol (50 ml) and hydrogenated at room temperature and pressure for 11 h. The mixture was filtered through hyflo and evaporated in vaco to afford the title compound as a colourless oil (2.45 g), t.l.c. (ether) Rf 0.55.

Aufarbeitung

  1. filtrationThe mixture was filtered through hyflo
  2. customevaporated in vaco

Quellen und Nachweise

ORD-Eintrag
ord-cc2096fb3ade4213ba15a74485b96ba4
Quelldatensatz
uspto-grants-1991_02
Patentnummer
US04996218

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