Hydroxylamine HCl → 1,5,6,7-Tetrahydro-indol-4-one oxime

HRID 983056

Reaktionsgleichung

Reaktionsgleichung von HRID 983056
[NH:1]1[C:9]2[CH2:8][CH2:7][CH2:6][C:5](=O)[C:4]=2[CH:3]=[CH:2]1.[Cl-].[OH:12][NH3+:13]>N1C=CC=CC=1>[NH:1]1[C:9]2[CH2:8][CH2:7][CH2:6][C:5](=[N:13][OH:12])[C:4]=2[CH:3]=[CH:2]1

Komponenten

4

Edukt 2

HCID 21645Hydroxylamine HClHCID 2802291,5,6,7-Tetrahydro-4H-indol-4-one

Produkt 1

HCID 9156771,5,6,7-Tetrahydro-indol-4-one oxime

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

To a stirred solution of 1,5,6,7-tetrahydro-indol-4-one (5.4 g) in pyridine (40 mL) was added hydroxyammonium chloride (2 eq.) at rt. After 2 hours, the solvent was removed and the residue was diluted with water and extracted with ethyl acetate. The combined extracts were washed with brine, dried and concentrated to give 5.5 g of 1,5,6,7-tetrahydro-indol-4-one oxime as a pale yellow solid.

Aufarbeitung

  1. customthe solvent was removed
  2. additionthe residue was diluted with water
  3. extractionextracted with ethyl acetate
  4. washThe combined extracts were washed with brine
  5. customdried
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-67cf765a192c41c893670e580db22e07
Quelldatensatz
uspto-grants-2005_03
Patentnummer
US06861418B2

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