Water → 1-methyl-2-[(2-nitrophenoxy)methyl]-1H-imidazole

HRID 983355Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 983355
[Na].[N+:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[OH:11])([O-:4])=[O:3].C(=O)([O-])[O-].[Na+].[Na+].Cl.[CH3:19][N:20]1[CH:24]=[CH:23][N:22]=[C:21]1[CH2:25]Cl.O>CN(C)C=O>[CH3:19][N:20]1[CH:24]=[CH:23][N:22]=[C:21]1[CH2:25][O:11][C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=1[N+:2]([O-:4])=[O:3]

Komponenten

6

Edukt 4

HCID 962WaterHCID 10340Sodium CarbonateHCID 27954062-(chloromethyl)-1-methyl-1H-imidazole hydrochlorideHCID 569236172-Nitrophenol, sodium salt

Produkt 1

HCID 225596511-methyl-2-[(2-nitrophenoxy)methyl]-1H-imidazoleAusbeute 41,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A solution of 1.92 g (11.97 mmol) of o-nitrophenol sodium salt, 3.8 g (35.9 mmol) of sodium carbonate, 2 g (11.97 mmol) of 1-methyl-2-chloromethylimidazole hydrochloride in 30 ml of N,N-dimethylformamide were heated at 50° C. for 2 hours. The mixture was then poured into water and extracted with ethylacetate. The organic layer was washed with brine, dried over sodium sulfate and evaporated, affording 1.17 g of the title compound, recrystallized from diethylether.

Aufarbeitung

  1. extractionextracted with ethylacetate
  2. washThe organic layer was washed with brine
  3. dry with materialdried over sodium sulfate
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-f0e12bf4cf334c17b16f95dd37920f4c
Quelldatensatz
uspto-grants-2005_03
Patentnummer
US06863647B2

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