1-(1-Benzylpyrrolidin-3-yl)ethan-1-one → HCID 22560190, Verbindung

HRID 983396Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 983396
[C:1]([CH:4]1[CH2:8][CH2:7][N:6]([CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:5]1)(=[O:3])[CH3:2].[BH4-].[Na+]>CO>[CH2:9]([N:6]1[CH2:7][CH2:8][CH:4]([CH:1]([OH:3])[CH3:2])[CH2:5]1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Komponenten

4

Edukt 2

HCID 3579521-(1-Benzylpyrrolidin-3-yl)ethan-1-oneHCID 4311764Sodium borohydride

Produkt 1

HCID 22560190HCID 22560190, VerbindungAusbeute 74,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a 5° C. solution of 3-acetyl-1-benzylpyrrolidine (1 g, 4.9 mmol [L. E. Overman, J. Am. Chem. Soc. 1983, 105, 6622]) in methanol (10 mL) was added portionwise sodium borohydride (0.37 g, 9.8 mmol). After stirring at room temperature for 17 hours, the mixture was concentrated, diluted with ethyl acetate, washed with water, brine, dried with sodium sulfate and concentrated to afford the title compound (0.75 g). MSCI: m/z=206 (MH+).

Aufarbeitung

  1. concentrationthe mixture was concentrated
  2. additiondiluted with ethyl acetate
  3. washwashed with water, brine
  4. dry with materialdried with sodium sulfate
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-8484d10411fa4e2f8592a0971fe058fc
Quelldatensatz
uspto-grants-2005_03
Patentnummer
US06864259B2

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