2,4-Dichloro-1,3,5-triazine → (4-Chloro-[1,3,5]triazin-2-yl)-[4-methoxy-3-(2-methoxy-ethoxy)-phenyl]amine

Temperatur

0 °C

2,4-Dichloro-1,3,5-triazine (89.1 mg, 0.5944 mmol) was dissolved in DMF (0.5 ml) and cooled to 0° C. To this solution were added DIEA (104 μl), 4-methoxy-3-(2-methoxy-ethoxy)phenylamine (TFA salt)(264 mg, ˜0.59 mmol) and DIEA (208 μl) in DMF (1 ml). The reaction mixture was kept at 0° C. for 15 to 30 min and then at RT for 15 min to 2 h. The reaction mixture was diluted with EtOAc and washed with brine. The organic layer was dried over Na2SO4, filtered, and evaporated in vacuo, to give (4-chloro-[1,3,5]triazin-2-yl)-[4-methoxy-3-(2-methoxy-ethoxy)-phenyl]amine.

1. waitat RT for 15 min to 2 h
2. washwashed with brine
3. dry with materialThe organic layer was dried over Na2SO4
4. filtrationfiltered
5. customevaporated in vacuo

ORD-Eintrag

ord-5260589d11c646f19ccd14bb6a3817b8

Quelldatensatz

uspto-grants-2005_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06864255B2