2,5-Dibromopyridine → 2-(Benzofuran-2-yl)-5-(thiophene-3-yl)pyridine

HRID 984756

Reaktionsgleichung

Reaktionsgleichung von HRID 984756
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[C:10]1[CH:15]=[CH:14][C:13](Br)=[CH:12][N:11]=1.BrC1C=CC(Br)=CN=1.O1C2C=CC=CC=2C=C1B(O)O.[S:37]1[CH:41]=[CH:40][C:39](B(O)O)=[CH:38]1>>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[C:10]1[CH:15]=[CH:14][C:13]([C:39]2[CH:40]=[CH:41][S:37][CH:38]=2)=[CH:12][N:11]=1

Komponenten

5

Edukt 4

HCID 693532,5-DibromopyridineHCID 581760Thiophene-3-boronic acidHCID 2776266Benzo[b]furan-2-boronic acidHCID 225083352-(Benzofuran-2-yl)-5-bromopyridine

Produkt 1

HCID 225083342-(Benzofuran-2-yl)-5-(thiophene-3-yl)pyridine

Versuchsvorschrift

It is easy to synthesis the following compound in the same manner as in Example 1 except that 2-(benzofuran-2-yl)-5-bromopyridine was synthesized from 2,5-dibromopyridine (made by Tokyo Kasei Kogyo K.K.) and 2-benzofuranboronic acid (made by Aldrich Co.) and is reacted with 3-thiopheneboronic acid (made by Aldrich Co.) to obtain 2-(benzofuran-2-yl)-5-(thiophene-3-yl)pyridine, which is used instead of 2-(5-trifluoromethylpyridine-2-yl)benzofuran.

Quellen und Nachweise

ORD-Eintrag
ord-c81d8596b33545ada16eb903414ed77a
Quelldatensatz
uspto-grants-2005_03
Patentnummer
US06869694B2

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