Imidazole → 1-(5-Nitro-2-methyl-phenylsulfonyl)-imidazole

HRID 985957

Reaktionsgleichung

Reaktionsgleichung von HRID 985957
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH3:14])=[C:8]([S:10](Cl)(=[O:12])=[O:11])[CH:9]=1)([O-:3])=[O:2].[NH:15]1[CH:19]=[CH:18][N:17]=[CH:16]1.O>N1C=CC=CC=1>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH3:14])=[C:8]([S:10]([N:15]2[CH:19]=[CH:18][N:17]=[CH:16]2)(=[O:12])=[O:11])[CH:9]=1)([O-:3])=[O:2]

Komponenten

5

Edukt 3

HCID 795ImidazoleHCID 962WaterHCID 8457o-Toluenesulfonyl chloride, 5-nitro-

Produkt 1

HCID 6850571-(5-Nitro-2-methyl-phenylsulfonyl)-imidazoleAusbeute 63,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

2.36 g of 5-nitro-2-methyl-phenylsulfonyl chloride (0.01 mol) and 1.36 g of imidazole (0.02 mol) were dissolved in 15 ml of pyridine, and the mixture was stirred at 50° C. for 3 hours to react. After the reaction, the reaction mixture was poured into water, and extracted with chloroform. The chloroform layer was washed with water and dehydrated. Evaporation of chloroform gave 1.70 g of 1-(5-nitro-2-methyl-phenylsulfonyl)-imidazole of the m.p. 119°-120° C.

Aufarbeitung

  1. customto react
  2. customAfter the reaction
  3. extractionextracted with chloroform
  4. washThe chloroform layer was washed with water
  5. customEvaporation of chloroform

Quellen und Nachweise

ORD-Eintrag
ord-fcb44b4c21584b2e92d076268a6bba5c
Quelldatensatz
uspto-grants-1987_12
Patentnummer
US04710509

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