Acetic Acid → Isopropyl 2-phenyl-4-quinolone-6-carboxylate

HRID 986239

Reaktionsgleichung

Reaktionsgleichung von HRID 986239
N[C@H:2]([CH:7]=O)[CH2:3]CSC.[C:9]1([C:15]2[CH2:24][C:23](=[O:25])[C:22]3[C:17](=[CH:18][CH:19]=[C:20]([C:26]([OH:28])=[O:27])[CH:21]=3)[N:16]=2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.C(O)(=O)C>C(O)(C)C>[C:9]1([C:15]2[CH2:24][C:23](=[O:25])[C:22]3[C:17](=[CH:18][CH:19]=[C:20]([C:26]([O:28][CH:2]([CH3:7])[CH3:3])=[O:27])[CH:21]=3)[N:16]=2)[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 446793Methionin ALHCID 704325112-Phenyl-4-quinolone-6-carboxylic acid

Produkt 1

HCID 70432651Isopropyl 2-phenyl-4-quinolone-6-carboxylateAusbeute 78,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

Metal sodium (0.33 gram) is dissolved in 40 ml of anhydrous isopropyl alcohol and the solution is heated to reflux for one hour with 2 grams of the 2-phenyl-4-quinolone-6-carboxylic acid obtained in Example 2. After cooling, the solution is mixed with ice water, acidified with acetic acid, the crystals which separate out therefrom are collected by filtration. The crystals are washed with water, washed with methanol, and dried to give 0.6 gram of isopropyl 2-phenyl-4-quinolone-6-carboxylate, colorless powder, melting at above 300° C.

Aufarbeitung

  1. temperaturethe solution is heated
  2. temperatureAfter cooling
  3. customthe crystals which separate out
  4. filtrationtherefrom are collected by filtration
  5. washThe crystals are washed with water
  6. washwashed with methanol
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-ec7b457643e94d7f8fa23723661d1b4e
Quelldatensatz
uspto-grants-1987_12
Patentnummer
US04711898

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