Sulfuryl chloride → 6-Amino-5,7-Dichloro-2-Methylbenzoxazole

HRID 9866

Reaktionsgleichung

Reaktionsgleichung von HRID 9866
[NH2:1][C:2]1[C:11]([Cl:12])=[CH:10][C:5]2[N:6]=[C:7]([CH3:9])[O:8][C:4]=2[CH:3]=1.S(Cl)([Cl:16])(=O)=O>C(OCC)(=O)C>[NH2:1][C:2]1[C:11]([Cl:12])=[CH:10][C:5]2[N:6]=[C:7]([CH3:9])[O:8][C:4]=2[C:3]=1[Cl:16]

Komponenten

4

Edukt 2

HCID 24648Sulfuryl chlorideHCID 112754042-Methyl-5-chloro-6-benzoxazolamine

Produkt 1

HCID 219887696-Amino-5,7-Dichloro-2-Methylbenzoxazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel2×

Versuchsvorschrift

6-Amino-5-chloro-2-methylbenzoxazole (10 g, 54.76 mMole) was dissolved in ethyl acetate (150 mL). At room temperature and with good stirring, sulfuryl chloride (8.8 mL, 109.52 mMole) was added drop by drop over a 20-minute period. As the addition proceeds, additional ethyl acetate (350 mL) was added to keep the mixture stirring. After 1 hour the precipitate was filtered off, washed with ether and air-dried. Yield 10.5 g.

Aufarbeitung

  1. additionwas added
  2. filtrationAfter 1 hour the precipitate was filtered off
  3. washwashed with ether
  4. customair-dried

Quellen und Nachweise

ORD-Eintrag
ord-e1a8a1d4fea343c68da40b757c689dec
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07091361B2

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