HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Boron trifluoride etherate → 2-fluoromethyl-3-(2-methyl-4-fluorophenyl)-6-nitro-4(3H)-quinazolinone
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Boron trifluoride etherate | HCID 8000 | — |
| Edukt | N-(2-fluoroacetamido-5-nitrobenzoyl)-2-methyl-4-fluoroaniline | HCID 13376458 | — |
| Lösungsmittel | Acetic Acid | HCID 176 | — |
| Produkt | 2-fluoromethyl-3-(2-methyl-4-fluorophenyl)-6-nitro-4(3H)-quinazolinone | HCID 13376466 | 79,1% |
Reaktionsschritte
4.0 g of N-(2-fluoroacetamido-5-nitrobenzoyl)-2-methyl-4-fluoraniline, 3.5 g of boron trifluoride etherate and 30 ml of acetic acid are treated in the same manner as described in Example 1-(2), whereby 3.0 g of 2-fluoromethyl-3-(2-methyl-4-fluorophenyl)-6-nitro-4(3H)-quinazolinone are obtained as colorless prisms.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04714702 |
| Quelldatensatz | uspto-grants-1987_12 |
| ORD ID | ord-89313873c7094478aba55d719ab59def |
| Quellennotiz | uspto-grants-1987_12 |