Diethyl Ether → HCID 178463964, Verbindung

HRID 986849

Reaktionsgleichung

Reaktionsgleichung von HRID 986849
[NH2:1][CH:2]([CH2:4][CH2:5][CH2:6][C:7]([C:10]1[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=1)([CH3:9])[CH3:8])[CH3:3].[H][H].CCOCC>Cl>[NH2:1][CH:2]([CH2:4][CH2:5][CH2:6][C:7]([C@H:10]1[CH2:15][CH2:14][C@H:13]([NH2:16])[CH2:12][CH2:11]1)([CH3:9])[CH3:8])[CH3:3]

Komponenten

5

Edukt 3

HCID 3283Diethyl EtherHCID 201566692-Amino-6-(4-aminophenyl)-6-methylheptaneHCID 178418361HCID 178418361, Verbindung2×

Produkt 1

HCID 178463964HCID 178463964, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

5.0 Parts of 2-amino-6-(4-aminophenyl)-6-methylheptane dissolved in 68 parts of 1N aqueous hydrochloric acid were shaken at room temperature and atmospheric pressure with hydrogen in the presence of 0.5 parts of Nishimura catalyst (rhodium-platinum oxides). Hydrogen uptake ceased at 105% of theory and the solution was filtered free of catalyst and treated with sodium hydroxide solution to give an oil which was isolated with ether. After removing the ether the residue was distilled to give 4.0 parts of cis and trans-2-amino-6-(4-aminocyclohexyl)-6-methyl-heptane b0.3 120°-9° with the following percentage composition by weight.

Aufarbeitung

  1. filtrationthe solution was filtered free of catalyst
  2. additiontreated with sodium hydroxide solution
  3. customto give an oil which
  4. customAfter removing the ether the residue
  5. distillationwas distilled

Quellen und Nachweise

ORD-Eintrag
ord-bbbe8691bcf548d4a8c7dcad54652f95
Quelldatensatz
uspto-grants-1987_12
Patentnummer
US04716248

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