2-(4-Benzyloxy-3-propoxyphenyl)-5,5-dimethyl-1,3-dioxane → HCID 22987076, Verbindung

HRID 987869Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 987869
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]2[O:20][CH2:19][C:18]([CH3:22])([CH3:21])[CH2:17][O:16]2)=[CH:11][C:10]=1[O:23][CH2:24][CH2:25][CH3:26])C1C=CC=CC=1>[Pd].O1CCCC1>[CH3:21][C:18]1([CH3:22])[CH2:17][O:16][CH:15]([C:12]2[CH:13]=[CH:14][C:9]([OH:8])=[C:10]([O:23][CH2:24][CH2:25][CH3:26])[CH:11]=2)[O:20][CH2:19]1

Komponenten

4

Edukt 1

HCID 229870842-(4-Benzyloxy-3-propoxyphenyl)-5,5-dimethyl-1,3-dioxane

Produkt 1

HCID 22987076HCID 22987076, VerbindungAusbeute 98,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of 1.07 g (3.00 mmol) of 2-(4-benzyloxy-3-propoxyphenyl)-5,5-dimethyl-1,3-dioxane, 15 ml of tetrahydrofuran and 107 g of 10% palladium/C hydrogenation catalyst was hydrogenated at room temperature. After the absorption of 62.4 ml of hydrogen, the reaction suspension was filtered through Dicalite and evaporated down. Chromatography of the residue over 25 g of silica gel using 19:1 toluene/ethyl acetate gave 790 mg of 4-(5,5-dimethyl-1,3-dioxan-2-yl)-2-propoxyphenol.

Aufarbeitung

  1. customwas hydrogenated at room temperature
  2. customAfter the absorption of 62.4 ml of hydrogen
  3. filtrationthe reaction suspension was filtered through Dicalite
  4. customevaporated down

Quellen und Nachweise

ORD-Eintrag
ord-a94e7249634744398b4e399e10a46b1a
Quelldatensatz
uspto-grants-2003_10
Patentnummer
US06632909B2

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