Toluene → 4-Hydroxy-3-propoxybenzaldehyde

HRID 987870Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 987870
CC1(C)CO[CH:5]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[C:10]([O:15][CH2:16][CH2:17][CH3:18])[CH:9]=2)[O:4]C1.C1(C)C=CC=CC=1>C(O)=O>[OH:14][C:11]1[CH:12]=[CH:13][C:8]([CH:5]=[O:4])=[CH:9][C:10]=1[O:15][CH2:16][CH2:17][CH3:18]

Komponenten

4

Edukt 2

HCID 1140TolueneHCID 22987076HCID 22987076, Verbindung

Produkt 1

HCID 17126234-Hydroxy-3-propoxybenzaldehydeAusbeute 0,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 284Formic AcidLösungsmittel

Versuchsvorschrift

A mixture of 1.26 g (4.74 mmol) of 4-(5,5-dimethyl-1,3-dioxan-2-yl)-2-propoxyphenol, 20 ml of toluene and 20 ml of formic acid was vigorously stirred for 2 hours at room temperature. Thereafter, the reaction mixture was partitioned between toluene and water and the organic phase was washed several times with water, dried over magnesium sulfate, filtered and evaporated down. Crystallization of the residue from a mixture of 10 ml of diethyl ether and 20 ml of hexane gave 0.78 mg of 4-hydroxy-3-propoxybenzaldehyde.

Aufarbeitung

  1. customThereafter, the reaction mixture was partitioned between toluene and water
  2. washthe organic phase was washed several times with water
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. customevaporated down
  6. customCrystallization of the residue
  7. additionfrom a mixture of 10 ml of diethyl ether and 20 ml of hexane

Quellen und Nachweise

ORD-Eintrag
ord-22979cd9413c4b5fa6b09df8a67e6f1c
Quelldatensatz
uspto-grants-2003_10
Patentnummer
US06632909B2

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