Nitric Acid → 1-Bromo-2,5-dimethyl-4-nitrobenzene

HRID 988933Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 988933
[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[CH3:9].[N+:10]([O-])([OH:12])=[O:11].S(=O)(=O)(O)O>C(OC(=O)C)(=O)C>[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([N+:10]([O-:12])=[O:11])=[CH:4][C:3]=1[CH3:9]

Komponenten

5

Edukt 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 11121Benzene, 2-bromo-1,4-dimethyl-

Produkt 1

HCID 8258081-Bromo-2,5-dimethyl-4-nitrobenzene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7918Acetic AnhydrideLösungsmittel

Versuchsvorschrift

740 g of bromo-p-xylene were initially introduced in acetic anhydride (ice-bath cooling) and nitrating acid (prepared from 400 ml of fuming nitric acid and 480 ml of concentrated sulfuric acid) was slowly added dropwise. During the addition, it was ensured that the internal temperature remained between 22° C.-25° C. When the addition was complete (duration about 5 hours), the ice bath was removed, and the mixture was stirred at RT for about a further 1 hour.

Aufarbeitung

  1. additionwas slowly added dropwise
  2. additionDuring the addition, it
  3. customremained between 22° C.-25° C
  4. additionWhen the addition
  5. customthe ice bath was removed

Quellen und Nachweise

ORD-Eintrag
ord-8b59aa4053fd431bafb677517bdcba32
Quelldatensatz
uspto-grants-2003_10
Patentnummer
US06638646B2

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