Hydrochloric Acid → 5-Amino-1-(1-methyl-4-phenyl-butyl)-1H-[1,2,3]triazole-4-carboxamide

HRID 989727Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 989727
[N:1]([CH:4]([CH3:14])[CH2:5][CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[N+:2]=[N-:3].[C:15]([CH2:17][C:18]([NH2:20])=[O:19])#[N:16].[Na].Cl>CS(C)=O.C(O)C>[NH2:16][C:15]1[N:1]([CH:4]([CH3:14])[CH2:5][CH2:6][CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:2]=[N:3][C:17]=1[C:18]([NH2:20])=[O:19]

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 7898CyanoacetamideHCID 5360545SodiumHCID 18419359(4-Azidopentyl)-benzene

Produkt 1

HCID 111499925-Amino-1-(1-methyl-4-phenyl-butyl)-1H-[1,2,3]triazole-4-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 679Dimethyl SulfoxideLösungsmittelHCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 997 mg (5.28 mmol) of (4-azidopentyl)-benzene and 672 mg (8 mmol) of cyanoacetamide in 3 ml of DMSO is admixed with a solution, of a temperature of 50° C., of 127 mg (5.5 mmol) of sodium in 3 ml of ethanol. The reaction mixture is stirred at room temperature for 15 h and then poured into 25 ml of ice-water. The pH is adjusted to pH 2 using 1N HCl and the precipitated solid is filtered off with suction, washed with water and dried under reduced pressure. This gives 1.14 g (79%) of a slightly yellow solid.

Aufarbeitung

  1. filtrationthe precipitated solid is filtered off with suction
  2. washwashed with water
  3. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-3ea34b4453f34c6aab93cd2bd85ca517
Quelldatensatz
uspto-grants-2002_10
Patentnummer
US06458796B1

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