Hydrochloric Acid → HCID 11220404, Verbindung

HRID 989898Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 989898
C[O:2][C:3]([C:5]1[N:6]=[C:7]([CH2:10][CH:11]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[O:8][CH:9]=1)=[O:4].[Li+].[I-].Cl>N1C=CC=CC=1>[C:3]([C:5]1[N:6]=[C:7]([CH2:10][CH:11]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[O:8][CH:9]=1)([OH:4])=[O:2]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 66321Lithium iodideHCID 23389069Ethyl (+/-)-4-(4-methoxycarbonyl-1,3-oxazol-2-yl)-3-phenylbutanoate

Produkt 1

HCID 11220404HCID 11220404, VerbindungAusbeute 80,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

A solution of ethyl (±)-4-(4-methoxycarbonyl-1,3-oxazol-2-yl)-3-phenylbutanoate (267 mg, 0.84 mmole) and LiI (338 mg, 2.52 mmole) in pyridine (5 mL) was heated to reflux. After 18 hr, the mixture was cooled to RT, poured into 10% HCl (150 mL), then extracted with CH2Cl2 (3×50 mL). The combined organic extracts were dried over MgSO4, filtered, and concentrated to give the title compound (205 mg, 80%) as a white solid: MS (ES) m/e 304 (M+H)+.

Aufarbeitung

  1. extractionextracted with CH2Cl2 (3×50 mL)
  2. dry with materialThe combined organic extracts were dried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-5588958b415d4be39f7d8d9071022f4e
Quelldatensatz
uspto-grants-2002_10
Patentnummer
US06458814B1

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