Sulfuric Acid → 2,2,2-Trifluoroethyl 3-hydroxybenzoate

Temperatur

95 °C

Into a 250 mL round bottom flask equipped with magnetic stirrer and heating mantle was added 10 parts of 3-hydroxy benzoic acid, 100 parts of 2,2,2-trifluoroethanol and 0.5 parts of concentrated sulfuric acid. The reaction mixture was heated at 95° C. for 48 hours. The solvent was evaporated under reduced pressure and the solid material was dissolved in 250 mL of ethyl acetate. The organic layer was washed with 250 mL of water, 250 mL 5% solution of sodium bicarbonate in 100 mL of water and finally with 250 mL of water. The ethyl acetate layer was dried over anhydrous sodium sulfate and the solvent was evaporated under reduced pressure, yield 4.1 parts. TLC on silica gel plate showed a single spot. The structure was confirmed on the basis of 1H NMR. The reaction proceeded as follows:

1. customInto a 250 mL round bottom flask equipped with magnetic stirrer
2. temperatureheating mantle
3. customThe solvent was evaporated under reduced pressure
4. dissolutionthe solid material was dissolved in 250 mL of ethyl acetate
5. washThe organic layer was washed with 250 mL of water, 250 mL 5% solution of sodium bicarbonate in 100 mL of water and finally with 250 mL of water
6. dry with materialThe ethyl acetate layer was dried over anhydrous sodium sulfate
7. customthe solvent was evaporated under reduced pressure
8. customyield 4.1 parts

ORD-Eintrag

ord-0c3ce822d4f34103a044cd3428658918

Quelldatensatz

uspto-grants-2002_10

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06461876B1