Isopropanol → 2-Chloro-6-(3-fluoro-phenyl-amino)-purine

HRID 9910

Reaktionsgleichung

Reaktionsgleichung von HRID 9910
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4](Cl)[N:3]=1.[F:12][C:13]1[CH:14]=[C:15]([CH:17]=[CH:18][CH:19]=1)[NH2:16].CN(C=O)C.C(O)(C)C>C(O)CCC>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4]([NH:16][C:15]2[CH:17]=[CH:18][CH:19]=[C:13]([F:12])[CH:14]=2)[N:3]=1

Komponenten

6

Edukt 4

HCID 3776IsopropanolHCID 6228DimethylformamideHCID 97423-FluoroanilineHCID 53244122,6-Dichloropurine

Produkt 1

HCID 219883282-Chloro-6-(3-fluoro-phenyl-amino)-purine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 2631-ButanolLösungsmittel

Versuchsvorschrift

2 g (10.58 mmol) of 2,6-dichloro-purine and 5.9 g (52.9 mmol) of 3-fluoro-aniline (Fluka, Buchs, Switzerland) are stirred in 60 ml of n-butanol and 3 ml of DMF at 80° C. for 5 h. The cooled reaction mixture is treated with isopropanol and the crystal mass which has precipitated out is filtered off and dried. 2-Chloro-6-(3-fluoro-phenyl-amino)-purine is obtained; m.p.>250° C.; FAB-MS: (M+H)+=264; Rf=0.3 (CH2Cl2:methanol 9:1).

Aufarbeitung

  1. customThe cooled reaction mixture
  2. customthe crystal mass which has precipitated out
  3. filtrationis filtered off
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-b882d8a91c4f492da930efef14481420
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07091346B1

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