Estradiol → Estradiol methyltestosterone

HRID 991390

Reaktionsgleichung

Reaktionsgleichung von HRID 991390
[CH3:1][C@@:2]12[C@H:12]3[CH2:13][CH2:14][C@:15]4([CH3:22])[C@:19]([OH:21])([CH3:20])[CH2:18][CH2:17][C@H:16]4[C@@H:11]3[CH2:10][CH2:9][C:8]1=[CH:7][C:5](=[O:6])[CH2:4][CH2:3]2.C[C@@]12[C@@H](O)CC[C@H]1[C@H]1[C@@H](C3C=CC(O)=CC=3CC1)CC2.C([O-])(=O)C=C.CC(O)COC(CO)C.C(O)CCCCCCC/C=C\CCCCCCCC>C(OCC)(=O)C.CCCCCC.C(O)(C)C>[CH3:22][C@@:15]12[C@@H:19]([OH:21])[CH2:18][CH2:17][C@H:16]1[C@H:11]1[C@@H:12]([C:2]3[CH:3]=[CH:4][C:5]([OH:6])=[CH:7][C:8]=3[CH2:9][CH2:10]1)[CH2:13][CH2:14]2.[CH3:1][C@@:2]12[C@H:12]3[CH2:13][CH2:14][C@:15]4([CH3:22])[C@:19]([OH:21])([CH3:20])[CH2:18][CH2:17][C@H:16]4[C@@H:11]3[CH2:10][CH2:9][C:8]1=[CH:7][C:5](=[O:6])[CH2:4][CH2:3]2

Komponenten

10

Edukt 6

HCID 5757EstradiolHCID 6010MethyltestosteroneHCID 25188AcrylateHCID 328812-(2-Hydroxypropoxy)-1-propanolHCID 5284499Oleyl AlcoholHCID 178527255HCID 178527255, Verbindung

Produkt 1

HCID 9829635Estradiol methyltestosterone

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 3776IsopropanolLösungsmittelHCID 8058HexaneLösungsmittelHCID 8857Ethyl AcetateLösungsmittel3×

Versuchsvorschrift

An estradiol/methyltestosterone pressure-sensitive adhesive mixture was prepared by combining 4.0 parts of methyltestosterone and 1.1 parts of estradiol in a solution of 42.3 parts of CAB-381-0.1 with 38.0 parts each of isopropyl alcohol and ethyl acetate. Then 76.5 parts of a polysiloxane adhesive (BIO-PSA® Q7-4502, a silicone in ethyl acetate; Dow Corning Corporation, Medical Products, Midland, Mich.), 48.8 parts of a polyacrylate adhesive (DURO-TAK® 87-2510, an acrylate copolymer in ethyl acetate and hexane; National Starch and Chemical Corporation, Bridgewater, N.J.), 8.0 parts of dipropylene glycol and 6.0 parts of oleyl alcohol were added and thoroughly mixed in an appropriate container until the mixture was completely homogeneous. The resulting composition had the ingredient concentrations on a dry weight percent basis (i.e., after evaporation of volatile solvents) as shown below.

Aufarbeitung

  1. additionthoroughly mixed in an appropriate container until the mixture
  2. concentrationthe ingredient concentrations
  3. customon a dry weight percent basis (i.e., after evaporation of volatile solvents)

Quellen und Nachweise

ORD-Eintrag
ord-84160a0d70d14e1087576ca7a0ef96f3
Quelldatensatz
uspto-grants-2002_10
Patentnummer
US06465004B1

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