Sodium Methoxide → HCID 22036378, Verbindung

HRID 991686Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 991686
Br[C:2]1[C:7]([O:8][CH2:9][CH2:10][OH:11])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:12][O-:13].[Na+]>CO>[OH:11][CH2:10][CH2:9][O:8][C:7]1[C:2]([O:13][CH3:12])=[N:3][CH:4]=[CH:5][CH:6]=1

Komponenten

4

Edukt 2

HCID 10942334Sodium MethoxideHCID 220362632-[(2-Bromopyridin-3-yl)oxy]ethan-1-ol

Produkt 1

HCID 22036378HCID 22036378, VerbindungAusbeute 45 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of the product obtained in Step 1 (2.33 g, 10.7 mmol) and NaOMe (0.634 mg, 11.8 mmol) in MeOH (50 mL) was refluxed overnight. The reaction mixture was filtered and concentrated. The residue was purified by column chromatography on silica, using CH2Cl2/MeOH/heptane (4:1:5) as eluent, to give 0.81 g (45%) of the title compound as a colorless oil.

Aufarbeitung

  1. temperaturewas refluxed overnight
  2. filtrationThe reaction mixture was filtered
  3. concentrationconcentrated
  4. customThe residue was purified by column chromatography on silica

Quellen und Nachweise

ORD-Eintrag
ord-000a0d7b546a49cc933a6a158c28495c
Quelldatensatz
uspto-grants-2002_10
Patentnummer
US06465467B1

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