1-Chloro-4-nitrobenzene → p-Fluoronitrobenzene

Temperatur

170 °C

157 g of 4-nitrochlorobenzene, 200 g of dimethylsulfoxide, 62.7 g of potassium fluoride, and 2.49 g of (N,N-dimethylimidazolidino)tetramethyl-guanidinium chloride were placed in a 1 liter four-neck flask equipped with thermometer, anchor stirrer, and reflux condenser with bubble counter. The mixture was heated with stirring to 170° C. and kept at this temperature for 5 hours. The reaction mixture was then cooled to room temperature, water was added at a volumetric ratio of 1:1, the phases that formed were separated, and, from the organic phase, by fractional distillation at reduced pressure, 4-nitrofluorobenzene was obtained in a yield of 96% of theory.

1. customequipped with thermometer, anchor stirrer
2. temperaturereflux condenser
3. customwith bubble counter
4. temperatureThe mixture was heated
5. temperatureThe reaction mixture was then cooled to room temperature
6. additionwater was added at a volumetric ratio of 1:1
7. customthe phases that formed
8. customwere separated
9. distillationfrom the organic phase, by fractional distillation at reduced pressure

ORD-Eintrag

ord-9a8619cf766f4e9b8699861270e51844

Quelldatensatz

uspto-grants-2006_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07091362B2