Hydrochloric Acid → 2-Bromo-4-chlorobenzene-1-thiol

Temperatur

23 °C

A solution of 2-bromo-4-chlorobenzene disulfide (3.8 g, 8.5 mmol) in THF (30 mL) was treated with NaBH4 (0.83 g, 22.0 mmol). The mixture was refluxed for a while and treated with MeOH (2 mL); heating was resumed for 0.5 hours. Mixture was cooled to 23° C., acidified with HCl (3N) and extracted with Et2O. The Et2O extracts were dried over MgSO4, filtered, and the filtrate was concentrated in vacuo to afford the title compound which was used without further purification.

1. temperatureThe mixture was refluxed for a while
2. temperatureheating
3. extractionextracted with Et2O
4. dry with materialThe Et2O extracts were dried over MgSO4
5. filtrationfiltered
6. concentrationthe filtrate was concentrated in vacuo

ORD-Eintrag

ord-03e0bdca654d4eacb7e9d8b325fa90b4

Quelldatensatz

uspto-grants-2002_10

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06469042B1