HCID 69915989, Verbindung → HCID 73990358, Verbindung
Reaktionsgleichung
[N:1]1([C:6]2[N:11]=[CH:10][C:9]([CH:12]=[CH:13][CH2:14][OH:15])=[CH:8][CH:7]=2)[CH:5]=[CH:4][CH:3]=[N:2]1>CC(C)=O.O=[Mn]=O>[N:1]1([C:6]2[N:11]=[CH:10][C:9]([CH:12]=[CH:13][CH:14]=[O:15])=[CH:8][CH:7]=2)[CH:5]=[CH:4][CH:3]=[N:2]1Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
A mixture of the compound from step C (185 mg, 0.92 mmol) and MnO2 (1.60 g, 18.40 mmol) in acetone (15 mL) was heated to reflux for 1 h. The cooled reaction mixture was filtered through Celite and the filtrate was concentrated. Purification by chromatography (SiO2, 2:1 hexane/ethyl acetate) yielded 78 mg (43%) of the title compound. MS 200 (M+H)+.
Aufarbeitung
- temperaturewas heated
- temperatureto reflux for 1 h
- customThe cooled reaction mixture
- filtrationwas filtered through Celite
- concentrationthe filtrate was concentrated
- customPurification by chromatography (SiO2, 2:1 hexane/ethyl acetate)
Quellen und Nachweise
- ORD-Eintrag
- ord-218df2ef5d3345749d8dfc3d3430dfcc
- Quelldatensatz
- uspto-grants-2002_10
- Patentnummer
- US06472372B1
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