Basic information
- CAS
5989-81-1- Standard SMILES
O.OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O- InChIKey
WSVLPVUVIUVCRA-KPKNDVKVSA-N- Molecular formula
- C12H24O12
- Average molar mass
- 360.31 g/mol
- Monoisotopic mass
- 360.1267762
Names & identifiers
- Preferred name
- alpha-Lactose monohydrate
- IUPAC
- (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol;hydrate
- English name
- Alpha-D-Lactose monohydrate
- Molecular formula
- C12H24O12
- Molecular weight
- 360.31
Names & synonyms
5989-81-1alpha-Lactose monohydrateDTXSID1052828alpha-D-Glucopyranose, 4-O-beta-D-galactopyranosyl-, monohydrateRefChem:1076517DTXCID90820517611-913-4Lactose monohydratealpha-D-Lactose monohydrateD-Lactose monohydrate64044-51-5Respitose
Show more names
α-Lactoseα-Lactose monohydrateα-D-Lactose monohydrateMILK SUGARALPHA-D-LACTOSEPharmatose 150MLACTOSE MONOHYDRATE (ALPHA-FORM)A-LACTOSE
alpha-lactose hydrateLactose monohydrate [NF](2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol;hydrateEWQ57Q8I5Xa-D-Glucopyranose, 4-O-b-D-galactopyranosyl-, monohydrateInhalac 120 (contains b anomer)d-(+)-lactose monohydrateLactose monohydrate (NF)
Database identifiers
- CAS
5989-81-1、64044-51-5、66857-12-3- PubChem CID
- 104938
- DTXSID
DTXSID1052828- ChEBI
CHEBI:189432- UNII
- EWQ57Q8I5X
- EC Number
- 611-913-4
Properties
Computed structural properties
- Topological polar surface area
- 191 Ų
- Hydrogen bond donors
- 9
- Hydrogen bond acceptors
- 12
- Rotatable bonds
- 4
- Heavy atoms
- 24
- Formal charge
- 0
- Complexity
- 382
Experimental & physicochemical properties
Physical DescriptionSolid; [Merck Index]
Physicochemical properties
- Melting point
- 219 °C · 219 °C
- Boiling point
- 412.35 °C · 412.35°C (rough estimate)
- alpha
- 20 · [α]D20+52.2～+52.8°
- Density
- 1 · 1,53 g/cm3
- refractive index
- 1.648 · 1.6480 (estimate)
- RTECS
- 9625000 · OD9625000
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- 2 O: · H2O: soluble1M, clear, colorless
- form
- Solid
- color
- White to Off-White
- PH
- pH (50g/l, 25℃) : 4.0～6.0
- biological source
- bovine milk
- Water Solubility
- Soluble in water.
- Stability
- Hygroscopic
- InChI
- 1S/C12H22O11.H2O/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17;/h3-20H,1-2H2;1H2/t3-,4-,5+,6+,7-,8-,9-,10-,11+,12+;/m1./s1
- InChIKey
- WSVLPVUVIUVCRA-KPKNDVKVSA-N
- SMILES
- [H]O[H].OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O
- CAS DataBase Reference
- 5989 · 5989-81-1(CAS DataBase Reference)
- EWG's Food Scores
- 1 · 1
- FDA UNII
- 57 Q8I5X · EWQ57Q8I5X
- EPA Substance Registry System
- 4 · .alpha.-D-Glucopyranose, 4-O-.beta.-D-galactopyranosyl-, hydrate (1:1) (5989-81-1)
- UNSPSC Code
- 85151701 · 85151701
- NACRES
- 75 · NA.75
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H315-H319-H335
- Precautionary statements
- 261 · P261-P301+P312-P302+P352-P304+P340-P305+P351+P338
- PPE
- 95 · Eyeshields, Gloves, type N95 (US)
- Hazard Codes
- Xi
- Risk Statements
- 40 · 40-36/37/38
- Safety Statements
- 24 · 24/25-36-26
- WGK Germany
- 3 · 3
- TSCA
- Yes
- HS Code
- 17021100 · 17021100
- Storage Class
- 11 · 11 - Combustible Solids
Safety & regulation
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 100% (63 of 63) of all reports.
Not Classified；Reported as not meeting GHS hazard criteria by 63 of 63 companies. For more detailed information, please visit ECHA C&L website.
Aggregated GHS information provided per 63 reports by companies from 2 notifications to the ECHA C&L Inventory.；Reported as not meeting GHS hazard criteria per 63 of 63 reports by companies.；There are 0 notifications provided by 0 of 63 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
Hazard information
Regulatory Information
Chemical: .alpha.-D-Glucopyranose, 4-O-.beta.-D-galactopyranosyl-, monohydrate
Chemical: D-Glucose, 4-O-.beta.-D-galactopyranosyl-, monohydrate
Lactose monohydrate: Does not have an individual approval but may be used under an appropriate group standard
Lactose monohydrate: Does not have an individual approval but may be used under an appropriate group standard
Other Safety Information
IMAP assessments - D-Glucose, 4-O-.beta.-D-galactopyranosyl-, monohydrate: Human health tier I assessment
IMAP assessments - .alpha.-D-Glucopyranose, 4-O-.beta.-D-galactopyranosyl-, monohydrate: Human health tier I assessment；Evaluation - Chemicals that are unlikely to require further regulation to manage risks to environment
Hazards SummaryThe standard milk sugar and lactose of pharmacy; [Merck Index] May cause irritation; [Sigma-Aldrich MSDS] See Lactose.
Hazard Classes and CategoriesNot Classified
Regulatory information
Regulatory Information
Chemical: .alpha.-D-Glucopyranose, 4-O-.beta.-D-galactopyranosyl-, monohydrate
Chemical: D-Glucose, 4-O-.beta.-D-galactopyranosyl-, monohydrate
Lactose monohydrate: Does not have an individual approval but may be used under an appropriate group standard
Lactose monohydrate: Does not have an individual approval but may be used under an appropriate group standard
Safety data
- PPE
- Eyeshields, Gloves, type N95 (US)
- wgk
- 3
- tsca
- Yes
- hs_code
- 17021100
- risk_code
- 40-36/37/38
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xi
- safety_code
- 24/25-36-26
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P301+P312-P302+P352-P304+P340-P305+P351+P338
Chemistry & industry
Uses & manufacturing
Uses
Found in the milk of mammals; Used as a nutrient, in baking mixtures, as pharmaceutic aid (tablet and capsule excipient and diluent), for lactic acid fermentation in ensilage and foods, in culture media, and as chromatographic adsorbent in analytical chemistry; [Merck Index]
Household ProductsInformation on 2 consumer products that contain alpha-Lactose monohydrate in the following categories is provided:；• Personal Care
Applications
Usesalpha-D-Lactose monohydrate is used as a carrier and stabiliser of aromas, pharmaceutical products, Food industry.
Suppliers100 total
国药集团化学试剂有限公司86-21-63210123 · [email protected]
山西锦洋药用辅料有限公司18234787927
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
上海惠诚生物科技有限公司60498804 18930850192 · [email protected]
上海康朗生物科技有限公司021-61998208 18217752821 · [email protected]
西安清言生物科技有限责任公司15339027915
广州隽沐生物科技股份有限公司020-36607679; 13502246435 · [email protected]
湖北金梭生物科技有限公司00123456789 · [email protected]
陕西帕尼尔生物科技有限公司029-84385017; +8613259417953 · [email protected]
河北展药生物科技有限公司15369953316 +8615369953316 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
上海晶抗生物工程有限公司021-54721350 13524668266 · [email protected]
大连美仑生物技术有限公司0411-62910999 13889544652 · [email protected]
北京绿百草科技发展有限公司010-61136123 · [email protected]
上海瀚鸿科技股份有限公司021-54306202 13764082696 · [email protected]
上海诗丹德标准技术服务有限公司021-021-57127007-6622-6622 17621252073 · [email protected]
上海泰坦科技股份有限公司400-6009262 15618770481 · [email protected]
合肥天健化工有限公司551-65418679 15856988503;15837135945 · [email protected]
玛雅试剂+86 (573) 82222445 (0)18006601000 452520369 · [email protected]
四川库利南科技有限公司400-1166-196 18981987031 · [email protected]
湖南汇百侍生物科技有限公司0731-85526065 13308475853 · [email protected]
Wuhan Demeikai Biotechnology Co., Ltd+8618942921723 · [email protected]
斯百全化学（上海）有限公司021-021-021-67601398-809-809-809 15221380277 · [email protected]
上海源叶生物科技有限公司13636370518 · [email protected]
赛默飞世尔科技（中国）有限公司800-810-5118 · [email protected]
北京伊诺凯科技有限公司400-810-7969 010-59572699 · [email protected]
深圳振强药物研发有限公司0755-66853366 13670046396 · [email protected]
南京杜莱生物技术有限公司025-84699383-8003;025-846993838003-8003 18013301590 · [email protected]
上海湄水化工科技有限公司021-60549325 18616193163
上海将来实业股份有限公司400-0066400 13621662912 · [email protected]
天津阿尔塔科技有限公司022-65378550-8551 · [email protected]
郑州鸿晟医药科技有限公司0371-0371-13526885213 15637198702 · [email protected]
四川省维克奇生物科技有限公司028-81700200 18116577057 · [email protected]
成都零六生物科技有限公司400-1166-196 13458535857 · [email protected]
广拓化学（上海）有限公司021-60899189-8001 18918189673 · [email protected]
上海麦克林生化科技股份有限公司15221275939 15221275939 · [email protected]
杭州杰恒化工有限公司0571-87396432 · [email protected]
上海孚一生物科技有限公司+86 (21) 61124340
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司021-61415566 800-8193336 · [email protected]
桦特昇生物科技（武汉）有限公司027-59207879 1972026995 18140587686 · [email protected]
潍坊市前进精细化工有限公司18753684562 · [email protected]
天津阿尔塔科技有限公司022-6537-8550 15522853686 · [email protected]
TargetMol中国（陶术生物）021-021-33632979 15002134094 · [email protected]
Hebei Runbin Biotechnology Co. LTD13180553332 · [email protected]
BOC Sciences16314854226 · [email protected]
九鼎化学（上海）科技有限公司4009209199 · [email protected]
湖北威德利化学试剂有限公司18327179646 · [email protected]
武汉鑫儒化工有限公司15927387915 15337108568
Alfa Chemistry+1-5166625404 · [email protected]
北京华威锐科化工科技有限公司89508211 18501085097 · [email protected]
Additional notes
DefinitionA sugar that occurs in many plants. It is extracted commercially from sugar cane and sugar beet. Sucrose is a disaccharide formed from a glucose unit and a fructose unit. It is hydrolyzed to a mixture of fructose and glucose by the enzyme invertase. Since this mixture has a different optical rotation (levorotatory) than the original sucrose, the mixture is called invert sugar.
Related reactions
3 records
Compound notes
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