alpha-Lactose monohydrate → alpha-D-lactose

HRID 1278174

Reaction equation

HRID 1278174 reaction equation
[OH:1][CH:2]1[O:21][C@H:20]([CH2:22][OH:23])[C@@H:7]([O:8][C@@H:9]2[O:17][C@H:16]([CH2:18][OH:19])[C@H:14]([OH:15])[C@H:12]([OH:13])[C@H:10]2[OH:11])[C@H:5]([OH:6])[C@H:3]1[OH:4].O.O[C@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O>>[OH:1][C@H:2]1[O:21][C@H:20]([CH2:22][OH:23])[C@@H:7]([O:8][C@@H:9]2[O:17][C@H:16]([CH2:18][OH:19])[C@H:14]([OH:15])[C@H:12]([OH:13])[C@H:10]2[OH:11])[C@H:5]([OH:6])[C@H:3]1[OH:4]

Participants

3

Reactant 2

HCID 104938alpha-Lactose monohydrate2×HCID 440995(+)-Lactose

Product 1

HCID 84571alpha-D-lactose

Procedure

As such it is already known to prepare anhydrous lactose from α-lactose hydrate. According to the U.S. Pat. No. 2,319,562 α-lactose hydrate is heated to a temperature, which is sufficiently high to set free the water of crystallization. However, the heated crystals must be present in a water vapour environment having a carefully controlled water vapour pressure. If the water vapour pressure is low, an unstable form of the anhydrous α-lactose is obtained. If the water vapour pressure is high, β-lactose is formed. The heating can be carried out in various manners, e.g. in an autoclave, in a rotary kiln, on a heated dish, in an organic solvent or on a roll drum drier.

Workup

  1. customthe water of crystallization

Sources & evidence

ORD record
ord-0eb1af14dc49464c8e0425104c25c3bd
Source dataset
uspto-grants-1981_07
Patent number
US04280997

Linked notes

Loading…