Basic information
- Standard SMILES
O=S([O-])[O-]- InChIKey
LSNNMFCWUKXFEE-UHFFFAOYSA-L- Molecular formula
- O3S-2
- Average molar mass
- 80.07 g/mol
- Monoisotopic mass
- 79.95791202
Overview
Sulfite is a sulfur oxoanion that is the conjugate base of hydrogen sulfite (H2SO3). It is a sulfur oxoanion, a sulfur oxide and a divalent inorganic anion. It is a conjugate base of a hydrogensulfite.
Names & identifiers
- Preferred name
- Sulfite
- IUPAC
- sulfite
Names & synonyms
sulfiteSulfite ion14265-45-3SulfitesDTXSID4049791CHEBI:1735915744271E9Inorganic SulfitesSulfites, InorganicRefChem:889548DTXCID1029750CHEBI:26823
Show more names
SulphiteSulfonateSulfite ionsSulfite dianiontrioxosulfate(2-)sulfurous acid, ion(2-)CHEBI:33543organosulfonate
Database identifiers
- CAS
14265-45-3- PubChem CID
- 1099
- DTXSID
DTXSID4049791- ChEBI
CHEBI:17359- UNII
- 15744271E9
- Nikkaji
- J283.049C
Properties
Computed structural properties
- XLogP
- -1.6
- Topological polar surface area
- 82.4 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 0
- Heavy atoms
- 4
- Formal charge
- -2
- Complexity
- 18.8
Experimental & physicochemical properties
Chemical ClassesOther Classes -> Sulfites
Safety & regulation
Hazard information
Regulatory InformationCommission Regulation (EC) No 451/2000
Hazards Summary
An estimated 5% of patients with asthma are sulfite sensitive. Following sensitization, type-I immediate hypersensitivity reactions occur after ingestion. Reactions in asthmatics may occur without evidence of type-I, Ig-E mediation. Patients may present with one or more of the following: flushing, fainting, sneezing, urticaria, angioedema, abdominal distress, bronchospasm, and anaphylaxis. [Ellenhorn, p. 1074] Occupational asthma confirmed in a water plant worker and food workers exposed to sulfites in dust or solution used as a preservative; [Malo] Metabisulfites are preservatives used in wines, salad bars, fruits, juices, and shrimp. Onset of symptoms is within minutes. Common symptoms are flushing, low blood pressure, and bronchospasm. [Goldfrank, p. 676] Sulfites are among the drugs and toxins that cause bronchospasm (Table I-3) and anaphylactoid-like reactions (Table I-17). [Olson, p. 8, 28] Sulfites are not classifiable as to carcinogenicity to humans. [IARC] See Potassium metabisulfite for a documented case of occupational asthma. See agents in the category, Sulfites.
Toxicology
Adverse EffectsAsthma - Reversible bronchoconstriction (narrowing of bronchioles) initiated by the inhalation of irritating or allergenic agents.
Carcinogen Classification
Sulfites
Group 3: Not classifiable as to its carcinogenicity to humans
Volume 54: (1992) Occupational Exposures to Mists and Vapours from Strong Inorganic Acids; and Other Industrial Chemicals
1992
1991
Chemistry & industry
Uses & manufacturing
Uses
Used as preservatives in foods, beverages, and medications; Drugs containing sulfites may include parenteral steroids, antibiotics, cardiovascular drugs, and other intravenous medications; also peritoneal dialysis solutions, local anesthetics, radiocontrast dyes, and other drugs; Sulfites used as preservatives include sulfur dioxide, potassium metabisulfite, sodium sulfite, sodium metabisulfite, sodium bisulfite, and potassium bisulfite. [Ellenhorn, p. 1074]
In 1987, the FDA withdrew approval for the use of sulfites in fresh vegetables. Prescription drugs containing sulfites and packaged foods containing sulfites >10 ppm must be labeled. [Ellenhorn, p. 1074]
Use ClassificationFood Additives -> FOOD_ADDITIVE -> JECFA Functional Classes
Related reactions
621 records
Linked notes
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