Basic information
- CAS
848142-62-1- Standard SMILES
Oc1ccc(-n2nc3ccc(O)cc3c2Cl)cc1- InChIKey
ZNHQDSBJVFFIAK-UHFFFAOYSA-N- Molecular formula
- C13H9ClN2O2
- Average molar mass
- 260.67 g/mol
- Monoisotopic mass
- 260.0352552
Names & identifiers
- Preferred name
- 3-chloro-2-(4-hydroxyphenyl)-2H-indazol-5-ol
- IUPAC
- 3-chloro-2-(4-hydroxyphenyl)indazol-5-ol
- English name
- 3-Chloro-2-(4-hydroxyphenyl)-2H-indazol-5-ol
- Molecular formula
- C13H9ClN2O2
- Molecular weight
- 260.68
Names & synonyms
3-chloro-2-(4-hydroxyphenyl)-2H-indazol-5-ol848142-62-1DTXSID40463812RefChem:93386DTXCID30414631Indazole-Cl3-chloro-2-(4-hydroxyphenyl)indazol-5-ol2H-Indazol-5-ol, 3-chloro-2-(4-hydroxyphenyl)-Ind-Cl73HT88ZAV4CHEMBL180071orb1702171
Show more names
SCHEMBL21423384GLXC-06942Indazole-Cl, >=98% (HPLC)EX-A10305AKOS030536245DB07708TS-08430DB-151563
Database identifiers
- CAS
848142-62-1- PubChem CID
- 11368987
- DTXSID
DTXSID40463812- ChEMBL
CHEMBL180071- UNII
- 73HT88ZAV4
- EC Number
- 804-387-4
- Nikkaji
- J3.001.051E
Properties
Computed structural properties
- XLogP
- 3.5
- Topological polar surface area
- 58.3 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 1
- Heavy atoms
- 18
- Formal charge
- 0
- Complexity
- 297
Experimental & physicochemical properties
DrugsPharmaceuticals -> Listed in ZINC15
Physicochemical properties
- storage temp.
- 2 · 2-8°C
- solubility
- 5 mg/mL · DMSO: >5mg/mL
- form
- powder
- color
- white to brown
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302
- Precautionary statements
- 280 · P280-P305+P351+P338
- Hazard Codes
- Xn
- Risk Statements
- 22 · 22
- WGK Germany
- 3 · 3
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 38 reports by companies from 1 notifications to the ECHA C&L Inventory.
Hazard information
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Safety data
- wgk
- 3
- risk_code
- 22
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xn
- Hazard statements
- H302
- Precautionary statements
- P280-P305+P351+P338
Chemistry & industry
Applications
UsesIndazole-Cl (Ind-Cl) is an Estrogen receptor (ER)-β-specific agonist with inflammatory effect. Indazole-Cl inhibits cyclooxygenase-2 exression reduction induced by hypoxia. And Indazole-Cl inhibits ROS production. Indazole-Cl also inhibits cell migration and invasion by hypoxia increased by hypoxia. Indazole-Cl is potent inhibitor of hypoxia-induced inammation in vascular smooth muscle cells (VSMCs)[1].
Suppliers8 total
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
天津诺康医药科技有限公司022-23989838 13810451150 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
南通全益生物科技有限公司0513-66337626 18051384581 · [email protected]
TargetMol中国（陶术生物）4008200310 15002144251 · [email protected]
BOC Sciences+1-631-485-4226 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
上海阿摩尔生物科技有限公司13370042665 18916960931 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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