HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-chloro-2-(4-hydroxyphenyl)-2H-indazol-5-ol
Indazole-Cl · 3-chloro-2-(4-hydroxyphenyl)indazol-5-ol · 3-Chloro-2-(4-hydroxyphenyl)-2H-indazol-5-ol · 2H-Indazol-5-ol, 3-chloro-2-(4-hydroxyphenyl)-
Identifiers & Physical Properties
| CAS No. | 848142-62-1 |
|---|---|
| Molecular formula | C13H9ClN2O2 |
| Average molar mass | 260.67 g/mol |
| Monoisotopic mass | 260.0352552 g/mol |
| SMILES | Oc1ccc(-n2nc3ccc(O)cc3c2Cl)cc1 |
| InChIKey | ZNHQDSBJVFFIAK-UHFFFAOYSA-N |
| PubChem CID | 11368987 |
| ChEMBL | CHEMBL180071 |
| EC No. | 804-387-4 |
| DTXSID | DTXSID40463812 |
Chemical & Physical Properties
| XLogP | 3.5 |
|---|---|
| Topological polar surface area | 58.3 |
| Hydrogen bond donors | 2 |
| Hydrogen bond acceptors | 3 |
| Rotatable bonds | 1 |
| Heavy atoms | 18 |
| Formal charge | 0 |
| Complexity | 297 |
| Drugs | Pharmaceuticals -> Listed in ZINC15 |
| Storage conditions | 2-8°C |
| Solubility | DMSO: >5mg/mL |
| Physical state | powder |
| Color | white to brown |
| GHS pictogram | GHS07 |
| Signal word | Warning |
| GHS hazard statements | H302 |
| GHS precautionary statements | P280-P305+P351+P338 |
| Hazard symbols | Xn |
| Risk statements (R) | 22 |
| Water hazard class (WGK) | 3 |
Safety & Regulations
| GHS classification | WarningH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 38 reports by companies from 1 notifications to the ECHA C&L Inventory. |
|---|---|
| Hazard Classes and Categories | Acute Tox. 4 (100%) |
| Water hazard class (WGK) | 3 |
| Risk statements (R) | 22 |
| Signal word | Warning |
| GHS pictogram | GHS07 |
| Hazard symbols | Xn |
| GHS hazard statements | H302 |
| GHS precautionary statements | P280-P305+P351+P338 |
Applications & Uses
Uses
Indazole-Cl (Ind-Cl) is an Estrogen receptor (ER)-β-specific agonist with inflammatory effect. Indazole-Cl inhibits cyclooxygenase-2 exression reduction induced by hypoxia. And Indazole-Cl inhibits ROS production. Indazole-Cl also inhibits cell migration and invasion by hypoxia increased by hypoxia. Indazole-Cl is potent inhibitor of hypoxia-induced inammation in vascular smooth muscle cells (VSMCs)[1].