Ethanesulfonyl chloride

Oil

Pale yellow

Soluble in carbon disulfide

Slightly soluble (decomposes) in water and alcohol; very soluble in ether and dichloromethane.

Danger

H302 (96.6%): Harmful if swallowed [Warning Acute toxicity, oral]

P260, P261, P262, P264, P270, P271, P280, P284, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P319, P320, P321, P330, P361+P364, P362+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 58 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Status: Active Update: 06-01-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/11864

Ethanesulphonyl chloride: Does not have an individual approval but may be used under an appropriate group standard

A lachrymator; All rats exposed to 1273 ppm died within 30 to 130 minutes; 4-hr LC50 (rat) = approximately 86 ppm; Rats exposed to lethal concentrations have lacrimation, salivation, gasping, and pulmonary hemorrhage; [HSDB] Reacts violently with water; A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Inhalation may cause chemical pneumonitis; Effects in high-dose animal studies include acute pulmonary edema; [MSDSonline]

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.

/LABORATORY ANIMALS: Acute Exposure/ A single dermal application of 2000 mg/kg to rabbits killed two of three animals. No deaths occurred following a dermal application of 200 mg/kg to rabbits.

/LABORATORY ANIMALS: Acute Exposure/ Acute (4-hr) inhalation studies indicated an LC50 of approximately 86 ppm in the rat. Clinical signs included eye irritation, lacrimation, salivation, and gasping. Decedents exhibited pulmonary hemorrhage. All rats died within 30 to 130 min during an exposure to 1273 ppm.

/LABORATORY ANIMALS: Acute Exposure/ Ethanesulfonyl chloride is corrosive to rabbit skin and eyes, and the vapor caused irritation of the eyes and respiratory tract. In rabbits, irritation of the eye 20 to 30 sec after instillation did not reduce the conjunctival necrosis, corneal opacity, or iridial changes. Corneal opacity persisted through 7 days.

LD50 rat oral 360 mg/kg

LC50 rat inhalation 86 ppm/4 hr

Used to make sulfonyl-substituted imides, methide lithium salts, and pentafluoroethanesulfonyl fluoride, a fluorinated surfactant; [HSDB]

Intermediate in the syntheses of new, low-cost, non-fluorinated, sulfonyl-substituted imide and methide lithium salts.

Intermediate in the preparation of the fluorinated surfactant pentafluoroethanesulfonyl fluoride.

Alkanesulfonyl chlorides are manufactured from mercaptans or disulfides and chlorine using a loop reactor having an ejector, wherein mercaptan or disulfide is dispersed or dissolved into circulating aqueous solvent before the ejector and alowed to react with chlorine supplied through the aspirator of the ejector.

Mercaptans or disulfide in aqueous solvents are reacted with chlorine gas in dark to produce alkanesulfonyl chloride without chloro chain byproducts. Thus, ... ethyl mercaptan was reacted with ... chlorine gas over 4 hours in /the/ dark in ... pure water keeping the reaction temperature under 20 °C to give ethanesulfonyl chloride.