Ethanesulfonyl chloride → N-(5-{3-[(ethylsulfonyl)amino]phenyl}-2,3-dihydro-1H-inden-2-yl)-2-propanesulfonamide

HRID 18425

Reaction equation

HRID 18425 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[CH2:13][CH:12]([NH:17][S:18]([CH:21]([CH3:23])[CH3:22])(=[O:20])=[O:19])[CH2:11]3)[CH:5]=[CH:6][CH:7]=1.[CH2:24]([S:26](Cl)(=[O:28])=[O:27])[CH3:25]>>[CH2:24]([S:26]([NH:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[CH2:13][CH:12]([NH:17][S:18]([CH:21]([CH3:23])[CH3:22])(=[O:20])=[O:19])[CH2:11]3)[CH:5]=[CH:6][CH:7]=1)(=[O:28])=[O:27])[CH3:25]

Participants

3

Reactant 2

HCID 11667Ethanesulfonyl chlorideHCID 46899970N-[5-(3-aminophenyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide

Product 1

HCID 11611549N-(5-{3-[(ethylsulfonyl)amino]phenyl}-2,3-dihydro-1H-inden-2-yl)-2-propanesulfonamide

Procedure

The title compound was prepared from Intermediate 4 and ethane sulfonyl chloride using the method of Example 4; mass spectrum (API): Found 421 (MH−), C20H26N2O4S2 requires 422; 1H-NMR (400 MHz, CDCl3): 1.42 (9H, m), 2.98 (2H, m), 3.18 (3H, m), 3.37 (2H, m), 4.36 (2H, m), 7.21 (2H, m), 7.29 (1H, m), 7.39 (4H, m).

Sources & evidence

ORD record
ord-1b10eb3f006e4ca5903f9547e477b874
Source dataset
uspto-grants-2010_06
Patent number
US07741351B2

Linked notes

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