Uracil (HCID 1174)｜Huagongshe

Names & identifiers

Preferred name: Uracil
IUPAC: 1H-pyrimidine-2,4-dione
English name: URACIL-5-D1
Molecular formula: C4H3DN2O2
Molecular weight: 113.09

Names & synonyms

uracil66-22-8pyrimidine-2,4(1H,3H)-dione2,4(1H,3H)-PyrimidinedionePyrodHybar X2,4-DioxopyrimidinePirod2,4-Pyrimidinedione1H-Pyrimidine-2,4-dione1,2,3,4-tetrahydropyrimidine-2,4-dioneDTXSID4021424

Show more names

Nsc29742Uracil-5-Uracil-5-DURACIL-5-D1[6-2H]-UracilURACIL (5-D, 98%)

NSC-3970SQ-6201SQ-7726SQ-8493CHEBI:17568BMS-205603-0156HH86ZVCTNSC3970

Database identifiers

CAS: 24897-50-5、2920-92-5、51953-14-1、51953-20-9、66-22-8
PubChem CID: 1174
DTXSID: DTXSID4021424
ChEMBL: CHEMBL566
ChEBI: CHEBI:17568
UNII: 56HH86ZVCT
EC Number: 200-621-9
Nikkaji: J4.842I

Properties

Computed structural properties

XLogP: -1.1
Topological polar surface area: 58.2 Å²
Hydrogen bond donors: 2
Hydrogen bond acceptors: 2
Rotatable bonds: 0
Heavy atoms: 8
Formal charge: 0
Complexity: 161

Experimental & physicochemical properties

LogP · 2 items

-1.07

LogS-1.48

Solubility · 2 items

3600

3.6 mg/mL

Melting Point · 2 items

338

330 °C

Caco2 Permeability-5.37

Physical Description · 2 items

Solid; [Merck Index] White powder; [Alfa Aesar MSDS]

Solid

Physicochemical properties

CAS Number Unlabeled: 66 · 66-22-8

Safety & regulation

GHS classification

GHS Classification · 6 items

This chemical does not meet GHS hazard criteria for 82.4% (14 of 17) of all reports.

Warning

H315 (11.8%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (11.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (11.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 17 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Reported as not meeting GHS hazard criteria per 14 of 17 reports by companies.；There are 3 notifications provided by 3 of 17 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Hazard information

Regulatory Information · 2 items

Status: Active Update: 31-01-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/19811

2,4(1H,3H)-Pyrimidinedione: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - 2,4(1H,3H)-Pyrimidinedione: Environment tier I assessment；IMAP assessments - 2,4(1H,3H)-Pyrimidinedione: Human health tier I assessment

Hazards SummaryMay cause irritation; [Alfa Aesar MSDS] See Uracil.

Hazard Classes and CategoriesSkin Irrit. 2 (11.8%)；Eye Irrit. 2A (11.8%)；STOT SE 3 (11.8%)

Regulatory information

Regulatory Information · 2 items

Status: Active Update: 31-01-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/19811

2,4(1H,3H)-Pyrimidinedione: Does not have an individual approval but may be used under an appropriate group standard

Chemistry & industry

Pharmacology

Tissue LocationsAll Tissues；Placenta；Prostate

Cellular LocationsExtracellular

Metabolite Pathways · 1 item

Beta Ureidopropionase Deficiency；beta-Alanine metabolism；Carnosinuria, carnosinemia；Dihydropyrimidinase Deficiency；GABA-Transaminase Deficiency；MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy)；Pyrimidine metabolism；UMP Synthase Deficiency (Orotic Aciduria)；Ureidopropionase Deficiency