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Water → 1-(4-Nitrophenyl)pyrimidine-2,4-dione

HRID 18534
Notes
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Reaction equation

HRID 18534 reaction equation
[NH:1]1[CH:6]=[CH:5][C:4](=[O:7])[NH:3][C:2]1=[O:8].F[C:10]1[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][CH:11]=1.C([O-])([O-])=O.[Cs+].[Cs+].O>CN(C=O)C>[N+:16]([C:13]1[CH:14]=[CH:15][C:10]([N:1]2[CH:6]=[CH:5][C:4](=[O:7])[NH:3][C:2]2=[O:8])=[CH:11][CH:12]=1)([O-:18])=[O:17]
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 4

HCID 962WaterHCID 1174UracilHCID 9590p-FluoronitrobenzeneHCID 10796Cesium carbonate

Product 1

HCID 112763381-(4-Nitrophenyl)pyrimidine-2,4-dione

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent
On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Conditions

Temperature
80 °C

Procedure

A mixture of 3.5 g 1H-Pyrimidine-2,4-dione and 3 g 1-Fluoro-4-nitro-benzene and 13.8 g Cs2CO3 in 60 mL DMF was heated to 80° C. for 12 h. This solution was poured on to 200 mL of water and the resulting precipitate was collected by filtration to yield a bright yellow crystalline product, which was dried under reduced pressure. Yield: 2.6 g.

Workup

  1. filtrationthe resulting precipitate was collected by filtration
  2. customto yield a bright yellow crystalline product, which
  3. customwas dried under reduced pressure

Sources & evidence

ORD record
ord-d6ab52a054f44054930b84bdf35417b4
Source dataset
uspto-grants-2010_06
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07741341B2

Reaction notes

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