2-Amino-2-methyl-1-propanol
Basic information
- CAS
124-68-5- Standard SMILES
CC(C)(N)CO- InChIKey
CBTVGIZVANVGBH-UHFFFAOYSA-N- Molecular formula
- C4H11NO
- Average molar mass
- 89.14 g/mol
- Monoisotopic mass
- 89.08406397
Overview
2-amino-2-methyl-1-propanol appears as a clear light colored liquid. Insoluble in water and about the same density as water. Flash point 172 °F. Used to make other chemicals.
Names & identifiers
- Preferred name
- 2-Amino-2-methyl-1-propanol
- IUPAC
- 2-amino-2-methylpropan-1-ol
- English name
- 2-Amino-2-methyl-1-propanol
- Molecular formula
- C4H11NO
- Molecular weight
- 89.14
Names & synonyms
2-Amino-2-methyl-1-propanol124-68-52-AminoisobutanolAminomethylpropanolIsobutanol-2-amineAMP Regular1-Propanol, 2-amino-2-methyl-2-AminodimethylethanolAmp-952-AMINO-2-METHYLPROPANOL2-Methyl-2-aminopropanolCorrguard 75
Show more names
2-AMINO-2-METHYLPROPAN-1-OLKarl Fischer2-methyl-2-amino-1-propanolmonoisobutanolamine2,2-Diethyl-ethanolamine2-amino-2-methyl-1-propano
Hydroxy-tert-butylamineAMP (thinner)2-Amino-2,2-dimethylethanolIsobutanolamine1,1-Dimethyl-2-hydroxyethylamine2-Hydroxymethyl-2-propylamine2-Methyl-2-aminopropanol-12-Amino-1-hydroxy-2-methylpropane
Database identifiers
- CAS
124-68-5- PubChem CID
- 11807
- DTXSID
DTXSID8027032- ChEMBL
CHEMBL122588- UNII
- LU49E6626Q
- EC Number
- 204-709-8
- Nikkaji
- J38.382A
Properties
Computed structural properties
- XLogP
- -0.8
- Topological polar surface area
- 46.3 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 1
- Heavy atoms
- 6
- Formal charge
- 0
- Complexity
- 42.8
Experimental & physicochemical properties
Chemical Classes
Nitrogen Compounds -> Amines, Aliphatic
Flammable agents - 2nd degree
Cosmetics
Cosmetic ingredients (Aminomethyl Propanol) -> CIR (Cosmetic Ingredient Review)
Cosmetic ingredients (Aminomethylpropanol) -> CIR (Cosmetic Ingredient Review)
Buffering
pHPH OF 0.1 AQ SOLN 11.3
SpringerMaterials PropertiesChemical diffusion
Density
0.935 (USCG, 1999) - Less dense than water; will float
0.934 @ 20 °C/20 °C
0.93 g/cm³
0.935
0.934 @25 °C
Color/FormCRYSTALLINE MASS
Solubility
MISCIBLE WITH WATER; SOL IN ALCOHOLS
Solubility in water: miscible
Flash Point
153 °F (USCG, 1999)
67 °C
67 °C CC
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H315: Causes skin irritation [Warning Skin corrosion/irritation]
P264, P264+P265, P273, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement)
This chemical does not meet GHS hazard criteria for 0.3% (12 of 4294) of reports.
Warning
H315 (99.7%): Causes skin irritation [Warning Skin corrosion/irritation]
Hazard information
Regulatory Information
Chemical: 1-Propanol, 2-amino-2-methyl-
1-Propanol, 2-amino-2-methyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1-Propanol, 2-amino-2-methyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
REACH registered substance: 2-amino-2-methylpropanol (EC: 204-709-8)
2-Amino-2-methyl-1-propanol: Does not have an individual approval but may be used under an appropriate group standard
The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
Other Safety InformationIMAP assessments - 1-Propanol, 2-amino-2-methyl-: Environment tier I assessment
DOT LabelCombustible Liquid
Fire Hazards
Special Hazards of Combustion Products: Emits toxic fumes during fire conditions. (USCG, 1999)
Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Above 67 °C explosive vapour/air mixtures may be formed.
Health Hazards
Chemistry & industry
Pharmacology
Absorption, Distribution and Excretion
METABOLISM AND DISTRIBUTION OF (3)H-LABELED 2-AMINO-2-METHYLPROPANOL WAS STUDIED IN RATS RECEIVING NORMAL OR CHOLINE-DEFICIENT DIETS. TRITIUM APPEARED IN THE SERUM OF BOTH GROUPS 30 MIN AFTER THE IP INJECTION BUT THE LEVEL WAS GENERALLY LOWER IN THE CHOLINE-DEFICIENT GROUP. RATS ON THE NORMAL DIET EXCRETED MORE OF THE AMINO ACID IN THE URINE THAN DID THE CHOLINE-DEFICIENT RATS IN BOTH GROUPS ONLY THE UNCHANGED AMINO ACID WAS EXCRETED. LIVERS FROM THE CHOLINE-DEFICIENT GROUP HAD A GREATER UPTAKE AND RETENTION OF THE LABEL THAN THOSE FROM NORMAL RATS. MOST OF THE LABEL WAS FOUND IN THE CYTOSOL OF BOTH LIVER AND KIDNEY.
Uses & manufacturing
Uses
CIR ingredient: Aminomethyl Propanol
CIR ingredient: Aminomethylpropanol
Used to make other chemicals (surface-active agents, vulcanization accelerators, and pharmaceuticals) and as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, leather dressings, textile specialties, polishes, cleaning compounds, and so-called soluble oils; Also used in hair sprays, wave sets, hair dyes, Pamabrom (drug), and absorbents for acidic gases; [Merck Index] Used as a pigment dispersant for water-based paints, resin solubilizer, corrosion inhibitor, protecting agent for carbonyl groups and in boiler-water treatment; [CHEMINFO]
Painting (Pigments, Binders, and Biocides) [Category: Paint]
IN SYNTH OF SURFACE-ACTIVE AGENTS, VULCANIZATION ACCELERATORS, PHARMACEUTICALS; ABSORBENT FOR ACIDIC GASES; EMULSIFYING AGENT FOR COSMETIC CREAMS AND LOTIONS, MINERAL OIL & PARAFFIN WAX EMULSIONS, LEATHER DRESSINGS, TEXTILE SPECIALTIES, POLISHES, CLEANING COMPOUNDS, SO-CALLED SOL OILS; INGREDIENT OF DIURETIC PAMABROM
U.S. Production2023: 10,000,000 - <50,000,000 lb
Consumer UsesNot Known or Reasonably Ascertainable
Industry UsesPigment
Related reactions
785 records
Compound notes
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