2-Amino-2-methyl-1-propanol → 2-[[(1-Oxo-1,3-dihydroisobenzofuran-5-yl)carbonyl]amino]-2-methyl-1-propanol

HRID 23182

Reaction equation

HRID 23182 reaction equation
C(O[C:4]([C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[C:11](=[O:12])[O:10][CH2:9]2)=[O:5])C.[NH2:16][C:17]([CH3:21])([CH3:20])[CH2:18][OH:19]>C1(C)C=CC=CC=1>[OH:19][CH2:18][C:17]([NH:16][C:4]([C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[C:11](=[O:12])[O:10][CH2:9]2)=[O:5])([CH3:21])[CH3:20]

Participants

4

Reactant 2

HCID 118072-Amino-2-methyl-1-propanolHCID 90088Ethyl 1,3-dihydro-1-oxoisobenzofuran-5-carboxylate

Product 1

HCID 111960052-[[(1-Oxo-1,3-dihydroisobenzofuran-5-yl)carbonyl]amino]-2-methyl-1-propanol

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Method B): 5-Ethoxycarbonylphthalid (82 g, 0.4 mole) is added to a solution of 2-amino-2-methylpropan-1-ol (44.6 g. 0.5 mole) in toluene (100 ml). The mixture is heated to reflux temperature for 24 hours. Upon cooling the title compound is filtered off and recrystallised from hot toluene.

Workup

  1. temperatureThe mixture is heated
  2. temperatureto reflux temperature for 24 hours

Sources & evidence

ORD record
ord-b1c7e6f305a2432c90684e7fd8d07359
Source dataset
uspto-grants-2005_02
Patent number
US06849749B2

Linked notes

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