7-Methylquinoline

HCID 11927

Basic information

CAS
612-60-2
Standard SMILES
Cc1ccc2cccnc2c1
InChIKey
KDYVCOSVYOSHOL-UHFFFAOYSA-N
Molecular formula
C10H9N
Average molar mass
143.18 g/mol
Monoisotopic mass
143.07349929

Overview

7-methylquinoline appears as clear yellow liquid or oil. (NTP, 1992)

Names & identifiers

Preferred name
7-Methylquinoline
IUPAC
7-methylquinoline
English name
7-Methylquinoline
Molecular formula
C10H9N
Molecular weight
143.19

Names & synonyms

7-METHYLQUINOLINE612-60-2m-ToluquinolineQuinoline, 7-methyl-CCRIS 2895DTXSID5025657EINECS 210-316-2UNII-EOW995K43CNSC 65665BRN 0110317EOW995K43CAI3-00850
Show more names
7-methyquinoline7-Methylchinolin7-methyl-quinolin7-Methylquinolinol7-MethylquiuolineQuinolinol,7-methyl-7-Methylquinoline>
NSC-65665METHYLQUINOLINE, 7-DTXCID0056575-20-07-00402 (Beilstein Handbook Reference)mToluquinolineQuinoline, 7methylRefChem:106391210-316-2

Database identifiers

CAS
612-60-2
PubChem CID
11927
DTXSID
DTXSID5025657
ChEMBL
CHEMBL1322524
UNII
EOW995K43C
EC Number
210-316-2
Nikkaji
J842G

Properties

Computed structural properties

XLogP
2.5
Topological polar surface area
12.9 Ų
Hydrogen bond donors
0
Hydrogen bond acceptors
1
Rotatable bonds
0
Heavy atoms
11

Experimental & physicochemical properties

Chemical ClassesNitrogen Compounds -> Quinolines
SpringerMaterials PropertiesBoiling point
LogP2.47
Density1.0609 at 68 °F (NTP, 1992) - Denser than water; will sink
Solubilityless than 1 mg/mL at 68 °F (NTP, 1992)
Flash Point230 °F (NTP, 1992)

Physicochemical properties

Melting point
35 · 35-37 °C(lit.)
Boiling point
258 °C · 258 °C(lit.)
Density
1.061 · 1.061
refractive index
1.607 to · 1.6070 to 1.6210
Flash point
230 °F · >230 °F
storage temp.
Room Temperature

Safety & regulation

GHS classification

GHS Classification · 4 items

Danger

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 45 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

DOT LabelCorrosive
Fire HazardsThis chemical is combustible. (NTP, 1992)
Health HazardsSYMPTOMS: This compound may be absorbed through the skin and it causes skin irritation. The vapor or mist is irritating to the eyes, mucous membranes and upper respiratory tract.
Hazards SummaryA skin irritant; Vapor or mist causes eye, mucous membranes, and upper respiratory tract irritation; May be absorbed through skin; [NTP] An irritant; Risk of irreversible adverse health effects; [Alfa Aesar MSDS] See Quinoline.
Reactive GroupAmides and Imides
Reactivity Profile · 1 item

7-METHYLQUINOLINE may be sensitive to exposure to light. May react vigorously with strong oxidizing agents and strong acids (NTP, 1992). Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Safety & protection

Fire FightingFires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
First Aid · 1 item

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Nonfire Spill Response · 1 item

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Isolation and EvacuationExcerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:
Personal Protective Equipment (PPE) · 1 item

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Safety data

PPE
dust mask type N95 (US), Eyeshields, Gloves
wgk
3
tsca
TSCA listed
rtecs
VC0560000
hs_code
29334900
risk_code
37/38-41

Chemistry & industry

Uses & manufacturing

General Manufacturing InformationQuinoline, 7-methyl-: ACTIVE
Applications · 2 items

Uses7-methylquinoline has been bioassayed as tumor initiator on the skin of Sencar mice.

General Description7-Methylquinoline is a reagent used in the preparation of diarylmethylpiperazines as potent opioid receptor agonists with improved side effects. Also used in the preparation of novel pyrazine compounds derived from 2-phenylquinolin-7-yl which act as potent insulin-like growth factor-I receptor inhibitors.

Suppliers100 total

国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
阿诺西(上海)生物技术有限公司400-1107768 15058188853 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
上海策嵘生物科技有限公司[email protected]

Related reactions

23 records

Compound notes

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