2-(Chloroethoxy)ethanol (HCID 12361)

Names & identifiers

Preferred name: 2-(Chloroethoxy)ethanol
IUPAC: 2-(2-chloroethoxy)ethanol
English name: 2-(2-Chloroethoxy)ethanol
Molecular formula: C4H9ClO2
Molecular weight: 124.57

Names & synonyms

2-(2-CHLOROETHOXY)ETHANOL628-89-7Diglycol chlorohydrinEthanol, 2-(2-chloroethoxy)-2-Chloroethyl 2-hydroxyethyl etherR2UP818L4INSC-2648DTXSID90608612-(Chloroethoxy)ethanolRefChem:460123DTXCID5043554211-059-9

Show more names

DIETHYLENE GLYCOL CHLOROHYDRINDEGCHoroet2-(2-ChLDiglycol Choroethoxy)ethanoL

2-(2-chloroethoxy)ethan-1-olDiglycol chlorhydrinDiethylene glycol monochlorohydrinC4H9ClO22-(2'-Chloroethoxy)ethanolEthylene Glycol Mono-2-chloroethyl EtherMFCD000028702-(2-chloroethoxy) ethanol

Database identifiers

CAS: 628-89-7
PubChem CID: 12361
DTXSID: DTXSID9060861
UNII: R2UP818L4I
EC Number: 211-059-9
Nikkaji: J34.792B

Properties

Computed structural properties

XLogP: 0
Topological polar surface area: 29.5 Å²
Hydrogen bond donors: 1
Hydrogen bond acceptors: 2
Rotatable bonds: 4
Heavy atoms: 7
Formal charge: 0
Complexity: 32.9

Experimental & physicochemical properties

SpringerMaterials PropertiesBoiling point

Physicochemical properties

Boiling point: 79 · 79-81 °C5 mm Hg(lit.)
Density: 1.18 g/mL · 1.18 g/mL at 25 °C(lit.)
vapor pressure: 22.66 Pa · 22.66Pa at 20℃
refractive index: 20 · n20/D 1.452(lit.)
Flash point: 195 °F · 195 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: SOLUBLE
form: Liquid
pka: 14.34 · 14.34±0.10(Predicted)
color: Clear
Water Solubility: SOLUBLE
BRN: 506015 · 506015
Stability: Stable. Incompatible with strong oxidizing agents.
InChI: 1S/C4H9ClO2/c5-1-3-7-4-2-6/h6H,1-4H2
InChIKey: LECMBPWEOVZHKN-UHFFFAOYSA-N
SMILES: OCCOCCCl
LogP: 0.301 at · 0.301 at 30℃
CAS DataBase Reference: 628 · 628-89-7(CAS DataBase Reference)
EWG's Food Scores: 1 · 1
FDA UNII: 2 UP818L4I · R2UP818L4I
NIST Chemistry Reference: 2 · Ethanol, 2-(2-chloroethoxy)-(628-89-7)
EPA Substance Registry System: 2 · Ethanol, 2-(2-chloroethoxy)- (628-89-7)
UNSPSC Code: 12352100 · 12352100
NACRES: 22 · NA.22
Symbol(GHS): 5 · GHS05,GHS07
Signal word: Danger
Hazard statements: 315 · H315-H318-H335
Precautionary statements: 261 · P261-P280-P305+P351+P338
target organs: Respiratory system
PPE: Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes: Xi
Risk Statements: 36 · 36/37/38-36
Safety Statements: 26 · 26-36-39
RIDADR: 3334 · UN 3334
WGK Germany: 2 · 2
RTECS: 1350000 · KK1350000
F: 19 · 19
TSCA: TSCA listed
HS Code: 29094990 · 29094990
Storage Class: 10 · 10 - Combustible liquids
Hazard Classifications: 1 Skin · Eye Dam. 1Skin Irrit. 2STOT SE 3
REACH Registrations: Active

Safety & regulation

GHS classification

GHS Classification · 4 items

Danger

H315 (48.1%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 210 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Regulatory Information · 2 items

Status: Active Update: 04-08-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/10550

Ethanol, 2-(2-chloroethoxy)-: Does not have an individual approval but may be used under an appropriate group standard

Hazard Classes and CategoriesSkin Irrit. 2 (48.1%)

Safety data

F: 19
PPE: Eyeshields, Gloves, type ABEK (EN14387) respirator filter
wgk: 2
tsca: TSCA listed
rtecs: KK1350000
ridadr: UN 3334
hs_code: 29094990
risk_code: 36/37/38-36
Signal word: Danger
Symbol(GHS): GHS05,GHS07
hazard_code: Xi
safety_code: 26-36-39
Storage Class: 10 - Combustible liquids
target organs: Respiratory system
Hazard statements: H315-H318-H335
REACH Registrations: Active
Hazard Classifications: Eye Dam. 1Skin Irrit. 2STOT SE 3
Precautionary statements: P261-P280-P305+P351+P338

Chemistry & industry

Uses & manufacturing

General Manufacturing InformationEthanol, 2-(2-chloroethoxy)-: ACTIVE

Applications · 3 items

Uses2-(2-Chloroethoxy)ethanol is a degradation product of Bis(2-Chloroethyl) Ether. 2-(2-Chloroethoxy)ethanol is a potential genotoxic impurity (PGI) in active pharmaceutical ingredients (APIs).

Uses2-(2-Chloroethoxy)ethanol is employed in the preparation of o-nitrophenylbromoacetaldehyde bis-2-(2-chloroethoxy)-ethyl acetal, quetiapine and 2-(2-azidoethoxy)ethanol.

Uses2-(2-Chloroethoxy)ethanol was used in the synthesis of o-nitrophenylbromoacetaldehyde bis-2-(2-chloroethoxy)-ethyl acetal, quetiapine (an antipsychotic drug) and 2-(2-azidoethoxy)ethanol.