Corticotropin (4-10)

HCID 123787

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Basic information

CAS: 4037-01-8
Standard SMILES: CSCC[C@H](N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)O
InChIKey: HAAUASBAIUJHAN-LXOXETEGSA-N
Molecular formula: C44H59N13O10S
Average molar mass: 962.1 g/mol
Monoisotopic mass: 961.4228563

Overview

part of ACTH molecule containing amino acids 4-10 of total 39 amino acid chain; heptapeptide common to MSH & ACTH; RN given refers to glycine cpd

Names & identifiers

Preferred name: Corticotropin (4-10)
IUPAC: (4S)-4-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-(carboxymethylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
English name: MET-GLU-HIS-PHE-ARG-TRP-GLY
Molecular formula: C44H59N13O10S
Molecular weight: 962.09

Names & synonyms

ACTH (4-10)4037-01-8corticotropin (4-10)Msh-acth (4-10)Met-glu-his-phe-arg-trp-glyhuman ACTH (4-10)porcine ACTH (4-10)J48AU3I790N-(N-(N(2)-(N-(N-(N-L-Methionyl-L-alpha-glutamyl)-L-histidyl)-L-phenylalanyl)-L-arginyl)-L-tryptophyl)glycinecorticotropin 4-10RefChem:109471ACTH(4-10)

Show more names

n-acetyl semax amidaten-acetyl semaxAc-Met-Glu-His-Phe-Pro-Gly-ProMEHFRWGa-MSH (4-10)ACTH (4-10) aACTH (4-10), HUMANL-MET-GLU-HIS-PHE-ARG-TRP-GLY

4-10-Semax(4S)-4-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-(carboxymethylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acidH-Met-Glu-His-Phe-Arg-Trp-Gly-OHACTH - msh (4-10)ACTH 4-10C44H59N13O10SMFCD001674824-10-Corticotropin

Database identifiers

CAS: 4037-01-8
PubChem CID: 123787
DTXSID: DTXSID001031210
ChEMBL: CHEMBL2028951
UNII: J48AU3I790
Nikkaji: J506.219E

Properties

Computed structural properties

XLogP: -2.9
Topological polar surface area: 409 Å²
Hydrogen bond donors: 13
Hydrogen bond acceptors: 14
Rotatable bonds: 29
Heavy atoms: 68
Formal charge: 0
Complexity: 1,740

Physicochemical properties

Density: 1.48 · 1.48±0.1 g/cm3(Predicted)
RTECS: 596950 · MC0596950
storage temp.: 20 °C · −20°C
pka: 3.32 · 3.32±0.10(Predicted)
form: Solid
color: White to off-white
Sequence: Met-Glu-His-Phe-Arg-Trp-Gly
InChIKey: HAAUASBAIUJHAN-LXOXETEGSA-N
SMILES: C(C1=CNC2=CC=CC=C12)[C@@H](C(=O)NCC(=O)O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CCSC)CC1NC=NC=1)CC1C=CC=CC=1
FDA UNII: 48 AU3I790 · J48AU3I790
WGK Germany: 3 · 3

Safety & regulation

Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.

Safety data

wgk: 3

Chemistry & industry

Pharmacology

MeSH Pharmacological ClassificationDrugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms.

Applications

UsesAdrenocorticotropic Hormone (ACTH) (4-10), human is a melanocortin 4 (MC4R) receptor agonist.

Suppliers75 total

Hangzhou Go Top Peptide Biotech0571-88211921 · [email protected]

Baoji Guokang Healthchem co.,ltd+8615604608665 15604608665 · [email protected]

Shandong Hanjiang Chemical Co., Ltd+86-0533-2066820 +8618369939125 · [email protected]

河北枫嘉新材料科技有限公司+86-0311-87836622 +86-18712993135 · [email protected]

Aladdin Scientific[email protected]

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Compound notes

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