Completing data — refresh the page later to see the latest
Basic information
- CAS
38275-34-2- Standard SMILES
CS(=O)(=O)c1ncc(Cl)c(C(=O)O)n1- InChIKey
WZUPWJVRWIVWEF-UHFFFAOYSA-N- Molecular formula
- C6H5ClN2O4S
- Average molar mass
- 236.636 g/mol
- Monoisotopic mass
- 235.96585532
Names & identifiers
- Preferred name
- 5-chloro-2-(methylsulfonyl)pyrimidine-4-carboxylic acid
- IUPAC
- 5-Chloro-2-(methanesulfonyl)pyrimidine-4-carboxylic acid
- English name
- 5-Chloro-2-(methylsulfonyl)pyrimidine-4-carboxylic acid
- Molecular formula
- C6H5ClN2O4S
- Molecular weight
- 236.63
Names & synonyms
PK11000PK11007PK-11000PK 11000PK11000 ，S8728PK11000, 10 mM in DMSOPK 11000PK-11000PK110002-methanesulfonyl-5-chloro-4-pyrimidinecarboxylic acid5-chloro-2-(Methylsulfonyl)-4-pyriMidinecarboxylic acid4-Pyrimidinecarboxylic acid, 5-chloro-2-(methylsulfonyl)-
Database identifiers
- CAS
38275-34-2- PubChem CID
- 1241459
- DTXSID
DTXSID50361315- ChEMBL
CHEMBL5193022- EC Number
- 843-218-9
- Nikkaji
- J1.708.857B
Properties
Physicochemical properties
- storage temp.
- 2 · Sealed in dry,2-8°C
- solubility
- 2 O: · H2O: soluble10mg/mL, clear
- form
- powder
- color
- white to beige
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 315 · H315-H319
- Precautionary statements
- 305 · P305+P351+P338
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H315-H319
- Precautionary statements
- P305+P351+P338
Chemistry & industry
Applications
DescriptionPK11000 is a stabilizer of mutant p53.1 It covalently binds to Cys182 and Cys277, increases the thermal stability, and inhibits the aggregation of the p53Y220C DNA-binding domain when used at a concentration of 1 mM. PK11000 selectively decreases the viability of mutant p53-expressing SW480 (p53R273H,P309S), NUGC-3 and Huh7 (p53Y220C), and MKN1 (p53V143A) cancer cells over wild-type p53-expressing NUGC-4, HuH-6, and SJSA-1 cancer cells. However, it is not selective between H1299 p53-/- and H1299 p53R175H non-small cell lung cancer (NSCLC) cells. PK11000 (15 µM) increases the expression of the p53 target genes p21 and PUMA and decreases the expression of the p53 target gene MDM2 in Huh7 and MKN1 cells. It also increases the levels of reactive oxygen species (ROS) in Huh7 and MKN1 cells.WARNING This product is not for human or veterinary use.
Upstream & downstream products
Upstream raw materials
Suppliers61 total
陕西缔都医药有限责任公司029-81124775 17791530730 · [email protected]
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
咸宁深蓝生物医药研发有限公司18171815831 · [email protected]
Related reactions
5 records
Compound notes
Loading…