Carbon Dioxide → 5-Chloro-2-methanesulfonylpyrimidine
Reaction equation
[Cl:1][C:2]1[C:3](C(O)=O)=[N:4][C:5]([S:8]([CH3:11])(=[O:10])=[O:9])=[N:6][CH:7]=1.C(=O)=O>C1(OC)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[N:4][C:5]([S:8]([CH3:11])(=[O:9])=[O:10])=[N:6][CH:7]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
5-Chloro-2-(methylsulfonyl)pyrimidine-4-carboxylic acid (5.7 g, 24 mmol) was refluxed in anisole (8 mL) until the evolution of carbon dioxide ceased. The reaction mixture was cooled to room temperature and filtered. The solid was washed with light petroleum ether (1×50 mL) and dried to obtain the title compound (4.10 g, 88% yield) as a light orange solid.
Workup
- filtrationfiltered
- washThe solid was washed with light petroleum ether (1×50 mL)
- customdried
Sources & evidence
- ORD record
- ord-3fb86334fa384e0dab4ce14d98102812
- Source dataset
- uspto-grants-2010_03
- Patent number
- US07671043B2
Reaction notes
Loading…