Tripotassium citrate

HCID 13344

Completing data — usually done within a minute

Basic information

CAS
7778-49-6
Standard SMILES
O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].[K+].[K+].[K+]
InChIKey
QEEAPRPFLLJWCF-UHFFFAOYSA-K
Molecular formula
C6H5K3O7
Average molar mass
306.39 g/mol
Monoisotopic mass
305.8946469

Names & identifiers

Preferred name
Tripotassium citrate
IUPAC
tripotassium;2-hydroxypropane-1,2,3-tricarboxylate

Names & synonyms

TRIPOTASSIUM CITRATE866-84-2KaliksirPotassium citrate anhydrousLitocitPorekalKajosUrocit KSeltz-KK citrateCitric acid, tripotassium saltPotassium tribasic citrate
Show more names
ACALKA86R1NVR0HW1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium saltDTXSID8027325RefChem:933490Anhydrous, Potassium CitrateDTXCID907325212-755-5

Database identifiers

CAS
7778-49-6、866-84-2
PubChem CID
13344
DTXSID
DTXSID8027325
ChEMBL
CHEMBL1200458
ChEBI
CHEBI:64733
UNII
86R1NVR0HW
EC Number
212-755-5、231-905-0
Nikkaji
J7.148J

Properties

Computed structural propertiesFilling in

Topological polar surface area
141 Ų
Hydrogen bond donors
1
Hydrogen bond acceptors
7
Rotatable bonds
2
Heavy atoms
16

Experimental & physicochemical properties

pH · 2 items

Between 7,5 and 9,0 (5 % aqueous solution)

THE AQ SOLN IS ALKALINE TO LITMUS; PH ABOUT 8.5

OdorODORLESS
TasteHAS COOLING, SALINE TASTE
Density1.98 @25 °C
Color/Form · 2 items

WHITE CRYSTALS, GRANULES, OR POWDER

TRANSPARENT CRYSTALS

Solubility · 3 items

1 G DISSOLVES IN 0.65 ML WATER

1 G DISSOLVES VERY SLOWLY IN 2.5 ML GLYCEROL

ALMOST INSOL IN ALCOHOL

Safety & regulation

GHS classification

GHS Classification · 6 items

This chemical does not meet GHS hazard criteria for 96.3% (572 of 594) of all reports.

Not Classified;Reported as not meeting GHS hazard criteria by 572 of 594 companies (only 3.7% companies provided GHS information). For more detailed information, please visit ECHA C&L website.

Aggregated GHS information provided per 594 reports by companies from 4 notifications to the ECHA C&L Inventory.;Reported as not meeting GHS hazard criteria per 572 of 594 reports by companies.;There are 2 notifications provided by 22 of 594 reports by companies with hazard statement code(s).;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

This chemical does not meet GHS hazard criteria for 100% (14 of 14) of all reports.

Not Classified;Reported as not meeting GHS hazard criteria by 14 of 14 companies. For more detailed information, please visit ECHA C&L website.

Aggregated GHS information provided per 14 reports by companies from 2 notifications to the ECHA C&L Inventory.;Reported as not meeting GHS hazard criteria per 14 of 14 reports by companies.;There are 0 notifications provided by 0 of 14 reports by companies with hazard statement code(s).;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Hazard information

Regulatory Information · 5 items

Chemical: 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:?) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:?) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:3) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:3) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 19-12-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/14309

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt: Human health tier I assessment
Hazards SummaryPotassium salts by mouth in doses less than 2 mEq/kg are usually not toxic in patients with normal renal function; [HSDB] May cause irritation; [MSDSonline]
FDA Requirements121.101; LIMITATIONS: GRAS SEQUESTRANT; GRAS MISCELLANEOUS AND/OR GENERAL-PURPOSE FOOD ADDITIVE.
EPA Safer ChemicalChemical: Potassium citrate, anhydrous; Green circle - The chemical has been verified to be of low concern based on experimental and modeled data.
Hazard Classes and Categories · 2 items

Not Classified

Not Classified

Safety & protection

Protective Action Criteria (PAC) · 3 items

2.1 [mg/m3]

23 [mg/m3]

140 [mg/m3]

Toxicology

Interactions12 OF 40 HEART PT TREATED WITH POTASSIUM CITRATE SHOWED SLIGHT MALABSORPTION OF VITAMIN B12. MECHANISM OF THE DISTURBANCE APPEARED TO BE ACIDIFICATION OF CONTENTS OF THE ILEUM.
Human Toxicity ExcerptsCONGENITAL MALFORMATIONS AND SURVIVAL IN RELATION TO THE FIRST TRIMESTER USE OF SPECIFIC DRUGS AND VACCINES ARE PRESENTED.

Regulatory information

Regulatory Information · 5 items

Chemical: 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:?) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:?) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:3) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:3) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 19-12-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/14309

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt: Does not have an individual approval but may be used under an appropriate group standard

FDA Requirements121.101; LIMITATIONS: GRAS SEQUESTRANT; GRAS MISCELLANEOUS AND/OR GENERAL-PURPOSE FOOD ADDITIVE.

Chemistry & industry

Pharmacology

FDA Pharmacological Classification · 5 items

86R1NVR0HW

POTASSIUM CITRATE ANHYDROUS

Mechanisms of Action [MoA] - Alkalinizing Activity

Established Pharmacologic Class [EPC] - Metabolic Alkalinizer

Potassium citrate anhydrous is a Metabolic Alkalinizer. The mechanism of action of potassium citrate anhydrous is as an Alkalinizing Activity.

MeSH Pharmacological Classification · 2 items

Agents that promote the excretion of urine through their effects on kidney function.

Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here.

Uses & manufacturing

Uses · 6 items

Used as a food additive (sequestrant, stabilizer, and buffer), a preservative for cut flowers, and a medication (potassium supplement, diuretic, expectorant, and alkalizer); [HSDB] Used as chemical intermediate; [MSDSonline]

MEDICATION

MEDICATION (VET)

SEQUESTRANT FOOD ADDITIVE

STABILIZER, BUFFER IN FOODS

IN PRESERVATION OF CUT FLOWERS

U.S. Production · 2 items

2023: 75,000 - <100,000 lb;2022: 75,000 - <100,000 lb;2021: 75,000 - <100,000 lb;2020: 50,000 - <250,000 lb

2023: 1,000,000 - <2,500,000 lb;2022: 2,500,000 - <4,000,000 lb;2021: 2,500,000 - <4,000,000 lb;2020: 1,000,000 - <2,500,000 lb

Consumer UsesSoil amendments (fertilizers);Emulsifier
Industry UsespH regulating agent;Soil amendments (fertilizers);Emulsifier
Methods of ManufacturingBY ADDING POTASSIUM BICARBONATE OR CARBONATE TO A SOLN OF CITRIC ACID UNTIL EFFERVESCENCE CEASES, FILTERING THE SOLN & EVAPORATION TO GRANULATION.
Formulations/Preparations · 3 items

POTASSIUM CITRATE, NF. POWDER, NF. TABLETS, 2.3 MEQ OF K+ AND 0.8 MEQ OF C6H5O7(3-) (250 MG), 2.8 MEQ OF K+ AND 0.9 MEQ OF C6H5O7(3-) (300 MG), AND 5.6 MEQ OF K+ AND 1.8 MEQ OF C6H5O7(3-) (600 MG).

IT IS AT LEAST 99% PURE.

GRADES: TECHNICAL; CP; NF; FCC.

Suppliers97 total

郑州阿尔法化工有限公司+86-18530059196 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
Hebei Chuanghai Biotechnology Co., Ltd+86-17732866630 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
上海莉凯化工技术有限公司16628776521 · [email protected]

Related reactions

21 records

Compound notes

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